Rubredoxin-NAD+ reductase

From Wikipedia, the free encyclopedia

In enzymology, a rubredoxin-NAD+ reductase (EC 1.18.1.1) is an enzyme that catalyzes the chemical reaction

2 reduced rubredoxin + NAD⁺ + H⁺ 2 oxidized rubredoxin + NADH

The 3 substrates of this enzyme are reduced rubredoxin, NAD⁺, and H⁺, whereas its two products are oxidized rubredoxin and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on iron-sulfur proteins as donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is rubredoxin:NAD+ oxidoreductase. Other names in common use include rubredoxin reductase, rubredoxin-nicotinamide adenine dinucleotide reductase, dihydronicotinamide adenine dinucleotide-rubredoxin reductase, reduced nicotinamide adenine dinucleotide-rubredoxin reductase, NADH-rubredoxin reductase, rubredoxin-NAD reductase, NADH: rubredoxin oxidoreductase, DPNH-rubredoxin reductase, and NADH-rubredoxin oxidoreductase. This enzyme participates in fatty acid metabolism. It has 2 cofactors: FAD, and Iron.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1BFY.

[edit] References

• IUBMB entry for 1.18.1.1
• BRENDA references for 1.18.1.1 (Recommended.)
• PubMed references for 1.18.1.1
• PubMed Central references for 1.18.1.1
• Google Scholar references for 1.18.1.1
• Peterson JA, Kusunose M, Kusunose E, Coon MJ (1967). "Enzymatic omega-oxidation. II. Function of rubredoxin as the electron carrier in omega-hydroxylation". J. Biol. Chem. 242: 4334–40. PMID 4294330. 
• "Enzymatic -oxidation. VI. Isolation of homogeneous reduced diphosphopyridine nucleotide-rubredoxin reductase" (1972). J. Biol. Chem. 247: 2109–16. PMID 4335861. 
• Ueda T, Coon MJ (1972). "Enzymatic oxidation. VII. Reduced diphosphopyridine nucleotide-rubredoxin reductase: properties and function as an electron carrier in hydroxylation". J. Biol. Chem. 247: 5010–6. PMID 4403503. 
• Petitdemange H, Marczak R, Blusson H, Gay R (1979). "Isolation and properties of reduced nicotinamide adenine dinucleotiderubredoxin oxidoreductase of Clostridium acetobutylicum". Biochem. Biophys. Res. Commun. 91: 1258–65. doi:10.1016/0006-291X(79)91202-6. PMID 526302. 

[edit] External links

The CAS registry number for this enzyme class is 9032-27-3.

• IUBMB entry for 1.18.1.1

• KEGG entry for 1.18.1.1

• BRENDA entry for 1.18.1.1

• NiceZyme view of 1.18.1.1

• EC2PDB: PDB structures for 1.18.1.1

• PRIAM entry for 1.18.1.1

• PUMA2 entry for 1.18.1.1

• IntEnz: Integrated Enzyme entry for 1.18.1.1

• MetaCyc entry for 1.18.1.1

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0015044: rubredoxin-NAD+ reductase

• AMIGO entry for GO code 0015044: rubredoxin-NAD+ reductase