Rubredoxin-NAD(P)+ reductase

From Wikipedia, the free encyclopedia

In enzymology, a rubredoxin-NAD(P)+ reductase (EC 1.18.1.4) is an enzyme that catalyzes the chemical reaction

reduced rubredoxin + NAD(P)+ oxidized rubredoxin + NAD(P)H + H⁺

The 3 substrates of this enzyme are reduced rubredoxin, NAD⁺, and NADP⁺, whereas its 4 products are oxidized rubredoxin, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on iron-sulfur proteins as donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is rubredoxin:NAD(P)+ oxidoreductase. Other names in common use include rubredoxin-nicotinamide adenine dinucleotide (phosphate) reductase, rubredoxin-nicotinamide adenine, dinucleotide phosphate reductase, NAD(P)+-rubredoxin oxidoreductase, and NAD(P)H-rubredoxin oxidoreductase. This enzyme participates in fatty acid metabolism.

[edit] References

• IUBMB entry for 1.18.1.4
• BRENDA references for 1.18.1.4 (Recommended.)
• PubMed references for 1.18.1.4
• PubMed Central references for 1.18.1.4
• Google Scholar references for 1.18.1.4
• Petitdemange H, Blusson H, Gay R (1981). "Detection of NAD(P)H--rubredoxin oxidoreductases in Clostridia". Anal. Biochem. 116: 564–70. doi:10.1016/0003-2697(81)90403-6. PMID 6274224. 
• Ma K, Adams MW (1999). "A hyperactive NAD(P)H:Rubredoxin oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus". J. Bacteriol. 181: 5530–3. PMID 10464233. 

[edit] External links

• IUBMB entry for 1.18.1.4

• KEGG entry for 1.18.1.4

• BRENDA entry for 1.18.1.4

• NiceZyme view of 1.18.1.4

• EC2PDB: PDB structures for 1.18.1.4

• PRIAM entry for 1.18.1.4

• PUMA2 entry for 1.18.1.4

• IntEnz: Integrated Enzyme entry for 1.18.1.4

• MetaCyc entry for 1.18.1.4

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0015045: rubredoxin-NAD(P)+ reductase

• AMIGO entry for GO code 0015045: rubredoxin-NAD(P)+ reductase