Rubber cis-polyprenylcistransferase

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In enzymology, a rubber cis-polyprenylcistransferase (EC 2.5.1.20) is an enzyme that catalyzes the chemical reaction

poly-cis-polyprenyl diphosphate + isopentenyl diphosphate $\rightleftharpoons$ diphosphate + a poly-cis-polyprenyl diphosphate longer by one C₅ unit

Thus, the two substrates of this enzyme are poly-cis-polyprenyl diphosphate and isopentenyl diphosphate, whereas its two products are diphosphate and poly-cis-polyprenyl diphosphate longer by one C5 unit.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is poly-cis-polyprenyl-diphosphate:isopentenyl-diphosphate polyprenylcistransferase. Other names in common use include rubber allyltransferase, rubber transferase, isopentenyl pyrophosphate cis-1,4-polyisoprenyl transferase, cis-prenyl transferase, rubber polymerase, and rubber prenyltransferase. This enzyme participates in biosynthesis of steroids.

[edit] References

IUBMB entry for 2.5.1.20
BRENDA references for 2.5.1.20 (Recommended.)
PubMed references for 2.5.1.20
PubMed Central references for 2.5.1.20
Google Scholar references for 2.5.1.20
Archer BL and Cockbain EG (1969). "Rubber transferase from Hevea brasiliensis latex". Methods Enzymol. 15: 476–480.
McMullen AI and McSweeney GP (1966). "The biosynthesis of rubber. Incorporation of isopentenyl pyrophosphate into purified rubber particles by a soluble latex-serum enzyme". Biochem. J. 101: 42–47.