RSF1

From Wikipedia, the free encyclopedia

Remodeling and spacing factor 1

Identifiers

RSF1; HBXAP; RSF-1; XAP8; p325

External IDs

OMIM: 608522 MGI: 2682305 HomoloGene: 41142

Gene ontology
Molecular Function:	• zinc ion binding • transcription activator activity • transcription repressor activity • ATPase activity • histone binding • metal ion binding
Cellular Component:	• nucleus • RSF complex
Biological Process:	• nucleosome assembly • chromatin remodeling • transcription • transcription initiation • nucleosome positioning • negative regulation of DNA binding • negative regulation of transcription, DNA-dependent • positive regulation of viral transcription

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_016578 (mRNA)
NP_057662 (protein)

XM_620529 (mRNA)
XP_620529 (protein)

Location

Chr 11: 77.05 - 77.21 Mb

Chr 7: 97.46 - 97.56 Mb

Pubmed search

[1]

[2]

Remodeling and spacing factor 1, also known as RSF1, is a human gene.^[1]

HBXAP is involved in transcription repression, transcription coactivation when associated with hepatitis B virus X protein (HBX), and chromatin remodeling and spacing when associated with SNF2H (MIM 603375).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: RSF1 remodeling and spacing factor 1.

[edit] Further reading

Lee TH, Elledge SJ, Butel JS (1995). "Hepatitis B virus X protein interacts with a probable cellular DNA repair protein.". J. Virol. 69 (2): 1107–14. PMID 7815490.
LeRoy G, Orphanides G, Lane WS, Reinberg D (1998). "Requirement of RSF and FACT for transcription of chromatin templates in vitro.". Science 282 (5395): 1900–4. PMID 9836642.
Shamay M, Barak O, Doitsh G, et al. (2002). "Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription.". J. Biol. Chem. 277 (12): 9982–8. doi:10.1074/jbc.M111354200. PMID 11788598.
Shamay M, Barak O, Shaul Y (2002). "HBXAP, a novel PHD-finger protein, possesses transcription repression activity.". Genomics 79 (4): 523–9. doi:10.1006/geno.2002.6717. PMID 11944984.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Loyola A, Huang JY, LeRoy G, et al. (2003). "Functional analysis of the subunits of the chromatin assembly factor RSF.". Mol. Cell. Biol. 23 (19): 6759–68. PMID 12972596.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase.". Genes Cells 9 (2): 105–20. PMID 15009096.
Huang JY, Shen BJ, Tsai WH, Lee SC (2004). "Functional interaction between nuclear matrix-associated HBXAP and NF-kappaB.". Exp. Cell Res. 298 (1): 133–43. doi:10.1016/j.yexcr.2004.04.019. PMID 15242768.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Shih IeM, Sheu JJ, Santillan A, et al. (2005). "Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma.". Proc. Natl. Acad. Sci. U.S.A. 102 (39): 14004–9. doi:10.1073/pnas.0504195102. PMID 16172393.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.