Rs6313

From Wikipedia, the free encyclopedia

rs6313 also called T102C is a gene variation—a single nucleotide polymorphism (SNP)—in the human HTR2A gene that codes for the 5-HT2A receptor.

A genetic study has found higher extraversion personality score among borderline personality disorder patients for the C-allele.[1] Another study found a slight association with novelty seeking among Italian mood disorder patients.[2] A Chinese study found no association with suicidal behavior.[3]

Meta-analysis seems to indicate that the SNP is not associated with schizophrenia.[4]

[edit] See also

  • rs6311, another SNP related to the HTR2A gene.
  • rs6314 (His452Tyr), another SNP related to the HTR2A gene.

[edit] External link

[edit] Reference

  1. ^ Xingqun Ni, Ramprasad Bismil, Kirsten Chan, Tricia Sicard, Natalie Bulgin, Shelley McMain and James L. Kennedy (November 2006). "Serotonin 2A receptor gene is associated with personality traits, but not to disorder, in patients with borderline personality disorder". Neuroscience Letters 408 (3): 214–219. doi:10.1016/j.neulet.2006.09.002. 
  2. ^ Alessandro Serretti, Raffaella Calati, Ina Giegling, Annette M. Hartmann, Hans-Jürgen Möller, Cristina Colombo and Dan Rujescu (August 2007). "5-HT2A SNPs and the Temperament and Character Inventory". Progress in Neuro-Psychopharmacology and Biological Psychiatry 31 (6): 1275–1281. doi:10.1016/j.pnpbp.2007.05.008. 
  3. ^ Jing Zhang, Yifeng Shen, Guang He, Xingwang Li, Junwei Meng, Shengzhen Guo, Huafang Li, Niufan Gu, Guoyin Feng and Lin He (February 2008). "Lack of association between three serotonin genes and suicidal behavior in Chinese psychiatric patients". Progress in Neuro-Psychopharmacology and Biological Psychiatry 32 (2): 467–471. doi:10.1016/j.pnpbp.2007.09.019. 
  4. ^ Meta-Analysis of All Published Schizophrenia-Association Studies (Case-Control Only) rs6313. Schizophrenia Research Forum. Retrieved on 2008-06-10.
 This genetics article is a stub. You can help Wikipedia by expanding it.