RPS6KB1

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Ribosomal protein S6 kinase, 70kDa, polypeptide 1
Identifiers
Symbol(s) RPS6KB1; PS6K; S6K; S6K1; STK14A; p70(S6K)-alpha; p70-S6K; p70-alpha
External IDs OMIM: 608938 HomoloGene: 81703
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6198 n/a
Ensembl ENSG00000108443 n/a
Uniprot P23443 n/a
Refseq NM_003161 (mRNA)
NP_003152 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 17: 55.33 - 55.38 Mb n/a
Pubmed search [1] n/a

Ribosomal protein S6 kinase, 70kDa, polypeptide 1, also known as RPS6KB1, is a human gene.[1]

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.[1]

[edit] References

  1. ^ a b Entrez Gene: RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1.

[edit] Further reading

  • Proud CG (1997). "p70 S6 kinase: an enigma with variations.". Trends Biochem. Sci. 21 (5): 181–5. PMID 8871403. 
  • Manning BD (2004). "Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis.". J. Cell Biol. 167 (3): 399–403. doi:10.1083/jcb.200408161. PMID 15533996. 
  • Grove JR, Banerjee P, Balasubramanyam A, et al. (1991). "Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini.". Mol. Cell. Biol. 11 (11): 5541–50. PMID 1922062. 
  • Moser BA, Dennis PB, Pullen N, et al. (1997). "Dual requirement for a newly identified phosphorylation site in p70s6k.". Mol. Cell. Biol. 17 (9): 5648–55. PMID 9271440. 
  • Alessi DR, Kozlowski MT, Weng QP, et al. (1998). "3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro.". Curr. Biol. 8 (2): 69–81. PMID 9427642. 
  • Pullen N, Dennis PB, Andjelkovic M, et al. (1998). "Phosphorylation and activation of p70s6k by PDK1.". Science 279 (5351): 707–10. PMID 9445476. 
  • Burnett PE, Blackshaw S, Lai MM, et al. (1998). "Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton.". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8351–6. PMID 9653190. 
  • Gout I, Minami T, Hara K, et al. (1998). "Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region.". J. Biol. Chem. 273 (46): 30061–4. PMID 9804755. 
  • Barcova M, Speth C, Kacani L, et al. (1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.". Pflugers Arch. 437 (4): 538–46. PMID 10089566. 
  • Couch FJ, Wang XY, Wu GJ, et al. (1999). "Localization of PS6K to chromosomal region 17q23 and determination of its amplification in breast cancer.". Cancer Res. 59 (7): 1408–11. PMID 10197603. 
  • Balendran A, Currie R, Armstrong CG, et al. (2000). "Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in vivo at Thr-412 as well as Thr-252.". J. Biol. Chem. 274 (52): 37400–6. PMID 10601311. 
  • Speth C, Joebstl B, Barcova M, Dierich MP (2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones.". AIDS 14 (6): 629–36. PMID 10807185. 
  • Wilson KF, Wu WJ, Cerione RA (2001). "Cdc42 stimulates RNA splicing via the S6 kinase and a novel S6 kinase target, the nuclear cap-binding complex.". J. Biol. Chem. 275 (48): 37307–10. doi:10.1074/jbc.C000482200. PMID 10973943. 
  • Armstrong JL, Bonavaud SM, Toole BJ, Yeaman SJ (2001). "Regulation of glycogen synthesis by amino acids in cultured human muscle cells.". J. Biol. Chem. 276 (2): 952–6. doi:10.1074/jbc.M004812200. PMID 11013237. 
  • Diggle TA, Subkhankulova T, Lilley KS, et al. (2001). "Phosphorylation of elongation factor-2 kinase on serine 499 by cAMP-dependent protein kinase induces Ca2+/calmodulin-independent activity.". Biochem. J. 353 (Pt 3): 621–6. PMID 11171059. 
  • Sapkota GP, Kieloch A, Lizcano JM, et al. (2001). "Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.". J. Biol. Chem. 276 (22): 19469–82. doi:10.1074/jbc.M009953200. PMID 11297520. 
  • Remy I, Michnick SW (2001). "Visualization of biochemical networks in living cells.". Proc. Natl. Acad. Sci. U.S.A. 98 (14): 7678–83. doi:10.1073/pnas.131216098. PMID 11438723. 
  • Wang X, Li W, Williams M, et al. (2001). "Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.". EMBO J. 20 (16): 4370–9. doi:10.1093/emboj/20.16.4370. PMID 11500364. 
  • Belham C, Comb MJ, Avruch J (2001). "Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase.". Curr. Biol. 11 (15): 1155–67. PMID 11516946. 
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