RPS6KA5

From Wikipedia, the free encyclopedia

Ribosomal protein S6 kinase, 90kDa, polypeptide 5

PDB rendering based on 1vzo.

Available structures: 1vzo

Identifiers

Symbol(s)

RPS6KA5; MGC1911; MSK1; MSPK1; RLPK

External IDs

OMIM: 603607 MGI: 1920336 HomoloGene: 48302

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • catalytic activity • protein serine/threonine kinase activity • protein binding • ATP binding • metallopeptidase activity • zinc ion binding • transferase activity
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • protein amino acid phosphorylation • proteolysis • response to stress • epidermal growth factor receptor signaling pathway • protein kinase cascade • response to external stimulus • histone phosphorylation • response to chemical stimulus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004755 (mRNA)
NP_004746 (protein)

NM_153587 (mRNA)
NP_705815 (protein)

Location

Chr 14: 90.41 - 90.6 Mb

Chr 12: 100.95 - 101.13 Mb

Pubmed search

[1]

[2]

Ribosomal protein S6 kinase, 90kDa, polypeptide 5, also known as RPS6KA5, is a human gene.^[1]

[edit] References

^ Entrez Gene: RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5.

[edit] Further reading

Chung J, Uchida E, Grammer TC, Blenis J (1997). "STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation.". Mol. Cell. Biol. 17 (11): 6508-16. PMID 9343414.
Deak M, Clifton AD, Lucocq LM, Alessi DR (1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.". EMBO J. 17 (15): 4426-41. doi:10.1093/emboj/17.15.4426. PMID 9687510.
Jain N, Zhang T, Fong SL, et al. (1999). "Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK).". Oncogene 17 (24): 3157-67. doi:10.1038/sj.onc.1202238. PMID 9872331.
New L, Zhao M, Li Y, et al. (1999). "Cloning and characterization of RLPK, a novel RSK-related protein kinase.". J. Biol. Chem. 274 (2): 1026-32. PMID 9873047.
Thomson S, Clayton AL, Hazzalin CA, et al. (1999). "The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase.". EMBO J. 18 (17): 4779-93. doi:10.1093/emboj/18.17.4779. PMID 10469656.
Lim CP, Cao X (1999). "Serine phosphorylation and negative regulation of Stat3 by JNK.". J. Biol. Chem. 274 (43): 31055-61. PMID 10521505.
Buck M, Poli V, van der Geer P, et al. (2000). "Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha.". Mol. Cell 4 (6): 1087-92. PMID 10635333.
Jiang C, Yu L, Tu Q, et al. (2000). "Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31-->q32.1 by radiation hybrid mapping.". Cytogenet. Cell Genet. 87 (3-4): 261-2. PMID 10702687.
Lizcano JM, Morrice N, Cohen P (2001). "Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.". Biochem. J. 349 (Pt 2): 547-57. PMID 10880354.
Hefner Y, Borsch-Haubold AG, Murakami M, et al. (2001). "Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases.". J. Biol. Chem. 275 (48): 37542-51. doi:10.1074/jbc.M003395200. PMID 10978317.
Arthur JS, Cohen P (2000). "MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells.". FEBS Lett. 482 (1-2): 44-8. PMID 11018520.
Sapkota GP, Kieloch A, Lizcano JM, et al. (2001). "Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.". J. Biol. Chem. 276 (22): 19469-82. doi:10.1074/jbc.M009953200. PMID 11297520.
Deb A, Zamanian-Daryoush M, Xu Z, et al. (2001). "Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3.". EMBO J. 20 (10): 2487-96. doi:10.1093/emboj/20.10.2487. PMID 11350938.
Liu G, Zhang Y, Bode AM, et al. (2002). "Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation.". J. Biol. Chem. 277 (11): 8810-6. doi:10.1074/jbc.M110477200. PMID 11777913.
Wiggin GR, Soloaga A, Foster JM, et al. (2002). "MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts.". Mol. Cell. Biol. 22 (8): 2871-81. PMID 11909979.
Markou T, Lazou A (2002). "Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase.". Biochem. J. 365 (Pt 3): 757-63. doi:10.1042/BJ20011828. PMID 11994045.
Toska K, Kleppe R, Armstrong CG, et al. (2002). "Regulation of tyrosine hydroxylase by stress-activated protein kinases.". J. Neurochem. 83 (4): 775-83. PMID 12421349.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Janknecht R (2003). "Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1).". Oncogene 22 (5): 746-55. doi:10.1038/sj.onc.1206185. PMID 12569367.
Dolled-Filhart M, Camp RL, Kowalski DP, et al. (2003). "Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis.". Clin. Cancer Res. 9 (2): 594-600. PMID 12576423.