RPS6KA4

From Wikipedia, the free encyclopedia

Ribosomal protein S6 kinase, 90kDa, polypeptide 4

Identifiers

RPS6KA4; MSK2; RSK-B

External IDs

OMIM: 603606 MGI: 1930076 HomoloGene: 69288

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • protein serine/threonine kinase activity • ribosomal protein S6 kinase activity • protein binding • ATP binding • transferase activity • mitogen-activated protein kinase p38 binding
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • protein amino acid phosphorylation • protein kinase cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001006944 (mRNA)
NP_001006945 (protein)

NM_019924 (mRNA)
NP_064308 (protein)

Location

Chr 11: 63.88 - 63.9 Mb

Chr 19: 6.9 - 6.91 Mb

Pubmed search

[1]

[2]

Ribosomal protein S6 kinase, 90kDa, polypeptide 4, also known as RPS6KA4, is a human gene.^[1]

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.^[1]

[edit] References

^ ^a ^b Entrez Gene: RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Xing J, Ginty DD, Greenberg ME (1996). "Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase.". Science 273 (5277): 959-63. PMID 8688081.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Deak M, Clifton AD, Lucocq LM, Alessi DR (1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.". EMBO J. 17 (15): 4426-41. doi:10.1093/emboj/17.15.4426. PMID 9687510.
Pierrat B, Correia JS, Mary JL, et al. (1998). "RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK).". J. Biol. Chem. 273 (45): 29661-71. PMID 9792677.
Du K, Montminy M (1999). "CREB is a regulatory target for the protein kinase Akt/PKB.". J. Biol. Chem. 273 (49): 32377-9. PMID 9829964.
Zhu S, Gerhard DS (1999). "A transcript map of an 800-kb region on human chromosome 11q13, part of the candidate region for SCA5 and BBS1.". Hum. Genet. 103 (6): 674-80. PMID 9921902.
Tomás-Zuber M, Mary JL, Lesslauer W (2000). "Control sites of ribosomal S6 kinase B and persistent activation through tumor necrosis factor.". J. Biol. Chem. 275 (31): 23549-58. doi:10.1074/jbc.M002586200. PMID 10806207.
Tomás-Zuber M, Mary JL, Lamour F, et al. (2001). "C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB).". J. Biol. Chem. 276 (8): 5892-9. doi:10.1074/jbc.M005822200. PMID 11035004.
Gudi T, Casteel DE, Vinson C, et al. (2001). "NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation.". Oncogene 19 (54): 6324-33. doi:10.1038/sj.onc.1204007. PMID 11175347.
Prymakowska-Bosak M, Misteli T, Herrera JE, et al. (2001). "Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin.". Mol. Cell. Biol. 21 (15): 5169-78. doi:10.1128/MCB.21.15.5169-5178.2001. PMID 11438671.
Wiggin GR, Soloaga A, Foster JM, et al. (2002). "MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts.". Mol. Cell. Biol. 22 (8): 2871-81. PMID 11909979.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Soloaga A, Thomson S, Wiggin GR, et al. (2003). "MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14.". EMBO J. 22 (11): 2788-97. doi:10.1093/emboj/cdg273. PMID 12773393.
Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.". Mol. Cell Proteomics 6 (3): 537-47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.
Gesser B, Johansen C, Rasmussen MK, et al. (2007). "Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1/2): possible role for its anti-psoriatic effect.". J. Invest. Dermatol. 127 (9): 2129-37. doi:10.1038/sj.jid.5700859. PMID 17495961.