RPS4X

From Wikipedia, the free encyclopedia

Ribosomal protein S4, X-linked

Identifiers

RPS4X; CCG2; DXS306; FLJ40595; SCAR; SCR10

External IDs

OMIM: 312760 MGI: 98158 HomoloGene: 87775

Gene ontology
Molecular Function:	• structural constituent of ribosome • rRNA binding
Cellular Component:	• intracellular • ribosome • cytosolic small ribosomal subunit (sensu Eukaryota)
Biological Process:	• regulation of progression through cell cycle • translation • multicellular organismal development • cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_001007 (mRNA)
NP_000998 (protein)

NM_009094 (mRNA)
NP_033120 (protein)

Location

Chr X: 71.41 - 71.41 Mb

n/a

Pubmed search

[1]

[2]

Ribosomal protein S4, X-linked, also known as RPS4X, is a human gene.^[1]

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, Y-linked (RPS4Y). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. This gene is not subject to X-inactivation. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[1]

[edit] References

^ ^a ^b Entrez Gene: RPS4X ribosomal protein S4, X-linked.

[edit] Further reading

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins.". Biochem. Cell Biol. 73 (11-12): 933-47. PMID 8722009.
Watanabe M, Furuno N, Goebl M, et al. (1992). "Molecular cloning of the human gene, CCG2, that complements the BHK-derived temperature-sensitive cell cycle mutant tsBN63: identity of CCG2 with the human X chromosomal SCAR/RPS4X gene.". J. Cell. Sci. 100 ( Pt 1): 35-43. PMID 1795030.
Fisher EM, Beer-Romero P, Brown LG, et al. (1991). "Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome.". Cell 63 (6): 1205-18. PMID 2124517.
Wiles MV, Alexander CM, Goodfellow PN (1988). "Isolation of an abundantly expressed sequence from the human X chromosome by differential screening.". Somat. Cell Mol. Genet. 14 (1): 31-9. PMID 2829364.
Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression.". Gene 146 (2): 199-207. PMID 8076819.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Zinn AR, Alagappan RK, Brown LG, et al. (1994). "Structure and function of ribosomal protein S4 genes on the human and mouse sex chromosomes.". Mol. Cell. Biol. 14 (4): 2485-92. PMID 8139551.
Watanabe M, Zinn AR, Page DC, Nishimoto T (1993). "Functional equivalence of human X- and Y-encoded isoforms of ribosomal protein S4 consistent with a role in Turner syndrome.". Nat. Genet. 4 (3): 268-71. doi:10.1038/ng0793-268. PMID 8358435.
Geerkens C, Just W, Held KR, Vogel W (1996). "Ullrich-Turner syndrome is not caused by haploinsufficiency of RPS4X.". Hum. Genet. 97 (1): 39-44. PMID 8557258.
Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.". Eur. J. Biochem. 239 (1): 144-9. PMID 8706699.
Omoe K, Endo A (1996). "Relationship between the monosomy X phenotype and Y-linked ribosomal protein S4 (Rps4) in several species of mammals: a molecular evolutionary analysis of Rps4 homologs.". Genomics 31 (1): 44-50. doi:10.1006/geno.1996.0007. PMID 8808278.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes.". Genome Res. 8 (5): 509-23. PMID 9582194.
Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders.". Genomics 72 (3): 223-30. doi:10.1006/geno.2000.6470. PMID 11401437.
Robinson RC, Turbedsky K, Kaiser DA, et al. (2001). "Crystal structure of Arp2/3 complex.". Science 294 (5547): 1679-84. doi:10.1126/science.1066333. PMID 11721045.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1-11. PMID 11790298.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.". Mol. Biol. Evol. 21 (2): 384-96. doi:10.1093/molbev/msh027. PMID 14660691.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.