RPS11

From Wikipedia, the free encyclopedia

Ribosomal protein S11

Identifiers

External IDs

OMIM: 180471 MGI: 1351329 HomoloGene: 88443

Gene ontology
Molecular Function:	• structural constituent of ribosome • rRNA binding
Cellular Component:	• intracellular • ribosome • cytosolic large ribosomal subunit (sensu Eukaryota) • cytosolic small ribosomal subunit (sensu Eukaryota)
Biological Process:	• translation

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_001015 (mRNA)
NP_001006 (protein)

NM_013725 (mRNA)
NP_038753 (protein)

Location

Chr 19: 54.69 - 54.69 Mb

n/a

Pubmed search

[1]

[2]

Ribosomal protein S11, also known as RPS11, is a human gene.^[1]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S17P family of ribosomal proteins. It is located in the cytoplasm. The gene product of the E. coli ortholog (ribosomal protein S17) is thought to be involved in the recognition of termination codons. This gene is co-transcribed with a small nucleolar RNA gene, which is located in its third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[1]

[edit] References

^ ^a ^b Entrez Gene: RPS11 ribosomal protein S11.

[edit] Further reading

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins.". Biochem. Cell Biol. 73 (11-12): 933-47. PMID 8722009.
Feo S, Davies B, Fried M (1992). "The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome.". Genomics 13 (1): 201-7. PMID 1577483.
Ferrari S, Manfredini R, Tagliafico E, et al. (1990). "Noncoordinated expression of S6, S11, and S14 ribosomal protein genes in leukemic blast cells.". Cancer Res. 50 (18): 5825-8. PMID 1697501.
Lott JB, Mackie GA (1988). "Sequence of a cloned cDNA encoding human ribosomal protein S11.". Nucleic Acids Res. 16 (3): 1205. PMID 3267208.
Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.". Eur. J. Biochem. 239 (1): 144-9. PMID 8706699.
Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes.". Genome Res. 8 (5): 509-23. PMID 9582194.
Higa S, Yoshihama M, Tanaka T, Kenmochi N (2000). "Gene organization and sequence of the region containing the ribosomal protein genes RPL13A and RPS11 in the human genome and conserved features in the mouse genome.". Gene 240 (2): 371-7. PMID 10580157.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1-11. PMID 11790298.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes.". Protein Sci. 14 (6): 1438-46. doi:10.1110/ps.041293005. PMID 15883184.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.