RPLP0

From Wikipedia, the free encyclopedia

Ribosomal protein, large, P0

Identifiers

RPLP0; P0; L10E; MGC111226; MGC88175; PRLP0; RPP0

External IDs

OMIM: 180510 MGI: 88066 HomoloGene: 6517

Gene ontology
Molecular Function:	• RNA binding • structural constituent of ribosome • protein binding
Cellular Component:	• intracellular • ribosome • cytosolic large ribosomal subunit (sensu Eukaryota)
Biological Process:	• translational elongation • ribosome biogenesis and assembly

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_001002 (mRNA)
NP_000993 (protein)

NM_007475 (mRNA)
NP_031501 (protein)

Location

Chr 12: 119.12 - 119.12 Mb

n/a

Pubmed search

[1]

[2]

Ribosomal protein, large, P0, also known as RPLP0, is a human gene.^[1]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[1]

[edit] References

^ ^a ^b Entrez Gene: RPLP0 ribosomal protein, large, P0.

[edit] Further reading

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins.". Biochem. Cell Biol. 73 (11-12): 933–47. PMID 8722009.
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317–20. PMID 1602151.
Rich BE, Steitz JA (1988). "Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly.". Mol. Cell. Biol. 7 (11): 4065–74. PMID 3323886.
Towbin H, Ramjoué HP, Kuster H, et al. (1982). "Monoclonal antibodies against eucaryotic ribosomes. Use to characterize a ribosomal protein not previously identified and antigenically related to the acidic phosphoproteins P1/P2.". J. Biol. Chem. 257 (21): 12709–15. PMID 6182142.
Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank.". Gene 150 (2): 243–50. PMID 7821789.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes.". Genome Res. 8 (5): 509–23. PMID 9582194.
"Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097–108. PMID 9847074.
Tchórzewski M, Boldyreff B, Issinger O, Grankowski N. "Analysis of the protein-protein interactions between the human acidic ribosomal P-proteins: evaluation by the two hybrid system.". Int. J. Biochem. Cell Biol. 32 (7): 737–46. PMID 10856704.
Chan SH, Hung FS, Chan DS, Shaw PC (2001). "Trichosanthin interacts with acidic ribosomal proteins P0 and P1 and mitotic checkpoint protein MAD2B.". Eur. J. Biochem. 268 (7): 2107–12. PMID 11277934.
Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders.". Genomics 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. PMID 11790298.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Tchórzewski M, Krokowski D, Rzeski W, et al. (2003). "The subcellular distribution of the human ribosomal "stalk" components: P1, P2 and P0 proteins.". Int. J. Biochem. Cell Biol. 35 (2): 203–11. PMID 12479870.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Shu H, Chen S, Bi Q, et al. (2004). "Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line.". Mol. Cell Proteomics 3 (3): 279–86. doi:10.1074/mcp.D300003-MCP200. PMID 14729942.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Villacé P, Marión RM, Ortín J (2004). "The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs.". Nucleic Acids Res. 32 (8): 2411–20. doi:10.1093/nar/gkh552. PMID 15121898.