RPL41

From Wikipedia, the free encyclopedia

Ribosomal protein L41

Identifiers

Gene ontology
Molecular Function:	• RNA binding • structural constituent of ribosome
Cellular Component:	• ribosome • cytosolic large ribosomal subunit (sensu Eukaryota)
Biological Process:	• translation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_001035267 (mRNA)
NP_001030344 (protein)

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n/a (protein)

Location

Chr 5: 55.28 - 55.28 Mb

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Pubmed search

[1]

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Ribosomal protein L41, also known as RPL41, is a human gene.^[1]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with the yeast ribosomal protein YL41, belongs to the L41E family of ribosomal proteins. It is located in the cytoplasm. The protein can interact with the beta subunit of protein kinase CKII and can stimulate the phosphorylation of DNA topoisomerase II-alpha by CKII. Two alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[1]

[edit] References

^ ^a ^b Entrez Gene: RPL41 ribosomal protein L41.

[edit] Further reading

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins.". Biochem. Cell Biol. 73 (11-12): 933–47. PMID 8722009.
Klaudiny J, von der Kammer H, Scheit KH (1992). "Characterization by cDNA cloning of the mRNA of a highly basic human protein homologous to the yeast ribosomal protein YL41.". Biochem. Biophys. Res. Commun. 187 (2): 901–6. PMID 1326959.
Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank.". Gene 150 (2): 243–50. PMID 7821789.
Lee JH, Kim JM, Kim MS, et al. (1997). "The highly basic ribosomal protein L41 interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase IIalpha by CKII.". Biochem. Biophys. Res. Commun. 238 (2): 462–7. doi:10.1006/bbrc.1997.7317. PMID 9299532.
Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes.". Genome Res. 8 (5): 509–23. PMID 9582194.
Go H, Miyado K, Taniguchi S (1999). "Genomic structure of the human ribosomal protein L41 gene.". Biochem. Mol. Biol. Int. 46 (6): 1227–31. PMID 9891856.
Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders.". Genomics 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
Ahn BH, Kim TH, Bae YS (2002). "Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins.". Mol. Cells 12 (2): 158–63. PMID 11710515.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.