RPH3AL

From Wikipedia, the free encyclopedia

Rabphilin 3A-like (without C2 domains)

Identifiers

External IDs

OMIM: 604881 MGI: 1923492 HomoloGene: 5078

Gene ontology
Molecular Function:	• cytoskeletal protein binding • zinc ion binding • Rab GTPase binding
Cellular Component:	• cytoplasm
Biological Process:	• intracellular protein transport • exocytosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006987 (mRNA)
NP_008918 (protein)

XM_358900 (mRNA)
XP_358900 (protein)

Location

Chr 17: 0.06 - 0.2 Mb

Chr 11: 75.65 - 75.74 Mb

Pubmed search

[1]

[2]

Rabphilin 3A-like (without C2 domains), also known as RPH3AL, is a human gene.^[1]

[edit] References

^ Entrez Gene: RPH3AL rabphilin 3A-like (without C2 domains).

[edit] Further reading

Kotake K, Ozaki N, Mizuta M, et al. (1997). "Noc2, a putative zinc finger protein involved in exocytosis in endocrine cells.". J. Biol. Chem. 272 (47): 29407–10. PMID 9367993.
Smith JS, Tachibana I, Allen C, et al. (1999). "Cloning of a human ortholog (RPH3AL) of (RNO)Rph3al from a candidate 17p13.3 medulloblastoma tumor suppressor locus.". Genomics 59 (1): 97–101. doi:10.1006/geno.1999.5864. PMID 10395805.
Fenster SD, Chung WJ, Zhai R, et al. (2000). "Piccolo, a presynaptic zinc finger protein structurally related to bassoon.". Neuron 25 (1): 203–14. PMID 10707984.
Haynes LP, Evans GJ, Morgan A, Burgoyne RD (2001). "A direct inhibitory role for the Rab3-specific effector, Noc2, in Ca2+-regulated exocytosis in neuroendocrine cells.". J. Biol. Chem. 276 (13): 9726–32. doi:10.1074/jbc.M006959200. PMID 11134008.
Goi T, Takeuchi K, Katayama K, et al. (2003). "Mutations of rabphillin-3A-like gene in colorectal cancers.". Oncol. Rep. 9 (6): 1189–92. PMID 12375017.
Milkereit P, Strauss D, Bassler J, et al. (2003). "A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits.". J. Biol. Chem. 278 (6): 4072–81. doi:10.1074/jbc.M208898200. PMID 12446671.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Fukuda M (2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2.". J. Biol. Chem. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.
Cardoso C, Leventer RJ, Ward HL, et al. (2003). "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3.". Am. J. Hum. Genet. 72 (4): 918–30. PMID 12621583.
Cheviet S, Coppola T, Haynes LP, et al. (2004). "The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis.". Mol. Endocrinol. 18 (1): 117–26. doi:10.1210/me.2003-0300. PMID 14593078.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Manabe S, Nishimura N, Yamamoto Y, et al. (2004). "Identification and characterization of Noc2 as a potential Rab3B effector protein in epithelial cells.". Biochem. Biophys. Res. Commun. 316 (1): 218–25. doi:10.1016/j.bbrc.2004.02.026. PMID 15003533.
Matsumoto M, Miki T, Shibasaki T, et al. (2004). "Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells.". Proc. Natl. Acad. Sci. U.S.A. 101 (22): 8313–8. doi:10.1073/pnas.0306709101. PMID 15159548.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.