RP6-213H19.1

From Wikipedia, the free encyclopedia

Serine/threonine protein kinase MST4

Identifiers

External IDs

OMIM: 300547 MGI: 1917665 HomoloGene: 84402

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • protein kinase activity • protein serine/threonine kinase activity • protein-tyrosine kinase activity • ATP binding • transferase activity • identical protein binding
Cellular Component:	• Golgi apparatus
Biological Process:	• protein amino acid phosphorylation • regulation of apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001042452 (mRNA)
NP_001035917 (protein)

XM_985225 (mRNA)
XP_990319 (protein)

Location

Chr X: 130.98 - 131.04 Mb

Chr X: 47.11 - 47.14 Mb

Pubmed search

[1]

[2]

Serine/threonine protein kinase MST4, also known as RP6-213H19.1, is a human gene.^[1]

The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: RP6-213H19.1 serine/threonine protein kinase MST4.

[edit] Further reading

Liu KC, Wang D (1975). "[Synthesis of n-substituted beta-methyl DL-aspartates as potential hypocholesteremics (author's transl)]". Arch. Pharm. (Weinheim) 308 (7): 564–70. PMID 1164178.
Qian Z, Lin C, Espinosa R, et al. (2001). "Cloning and characterization of MST4, a novel Ste20-like kinase.". J. Biol. Chem. 276 (25): 22439–45. doi:10.1074/jbc.M009323200. PMID 11306563.
Dan I, Watanabe NM, Kusumi A (2001). "The Ste20 group kinases as regulators of MAP kinase cascades.". Trends Cell Biol. 11 (5): 220–30. PMID 11316611.
Lin JL, Chen HC, Fang HI, et al. (2001). "MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway.". Oncogene 20 (45): 6559–69. doi:10.1038/sj.onc.1204818. PMID 11641781.
Dan I, Ong SE, Watanabe NM, et al. (2002). "Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties.". J. Biol. Chem. 277 (8): 5929–39. doi:10.1074/jbc.M110882200. PMID 11741893.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Sung V, Luo W, Qian D, et al. (2003). "The Ste20 kinase MST4 plays a role in prostate cancer progression.". Cancer Res. 63 (12): 3356–63. PMID 12810671.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Preisinger C, Short B, De Corte V, et al. (2004). "YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta.". J. Cell Biol. 164 (7): 1009–20. doi:10.1083/jcb.200310061. PMID 15037601.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Chan EH, Nousiainen M, Chalamalasetty RB, et al. (2005). "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1.". Oncogene 24 (12): 2076–86. doi:10.1038/sj.onc.1208445. PMID 15688006.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Ma X, Zhao H, Shan J, et al. (2007). "PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway.". Mol. Biol. Cell 18 (6): 1965–78. doi:10.1091/mbc.E06-07-0608. PMID 17360971.