ROCK1

From Wikipedia, the free encyclopedia

Rho-associated, coiled-coil containing protein kinase 1

PDB rendering based on 1s1c.

Available structures: 1s1c, 2esm, 2etk, 2eto, 2etr

Identifiers

Symbol(s)

ROCK1; MGC131603; MGC43611; P160ROCK

External IDs

OMIM: 601702 MGI: 107927 HomoloGene: 55899

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • ATP binding • zinc ion binding • transferase activity • diacylglycerol binding • identical protein binding • metal ion binding
Cellular Component:	• intracellular • cytoskeleton
Biological Process:	• protein amino acid phosphorylation • apoptosis • intracellular signaling cascade • Rho protein signal transduction • actin cytoskeleton organization and biogenesis • negative regulation of neuron apoptosis

Orthologs

Human

Mouse

Entrez

6093

19877

Refseq

NM_005406 (mRNA)
NP_005397 (protein)

NM_009071 (mRNA)
NP_033097 (protein)

Pubmed search

[1]

[2]

Rho-associated, coiled-coil containing protein kinase 1, also known as ROCK1, is a protein serine/threonine kinase, but also denotes the human gene encoding it.

It is activated when bound to the GTP-bound form of Rho GTPase. This protein is thus a downstream effector of Rho. It phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.^[1] Thus, ROCK1 contributes to actin-stability.

[edit] See also

Rho kinase

[edit] References

^ Entrez Gene: ROCK1 Rho-associated, coiled-coil containing protein kinase 1.

[edit] Further reading

Riento K, Ridley AJ (2003). "Rocks: multifunctional kinases in cell behaviour.". Nat. Rev. Mol. Cell Biol. 4 (6): 446–56. doi:10.1038/nrm1128. PMID 12778124.