ROBO4

From Wikipedia, the free encyclopedia

Roundabout homolog 4, magic roundabout (Drosophila)

Identifiers

ROBO4; FLJ20798; MGC133352; MGC133353; MRB

External IDs

OMIM: 607528 MGI: 1921394 HomoloGene: 10397

Gene ontology
Molecular Function:	• receptor activity
Cellular Component:	• integral to membrane
Biological Process:	• angiogenesis • multicellular organismal development • cell differentiation • regulation of cell migration

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_019055 (mRNA)
NP_061928 (protein)

NM_028783 (mRNA)
NP_083059 (protein)

Location

Chr 11: 124.26 - 124.27 Mb

Chr 9: 37.15 - 37.16 Mb

Pubmed search

[1]

[2]

Roundabout homolog 4, magic roundabout (Drosophila), also known as ROBO4, is a human gene.^[1]

[edit] References

^ Entrez Gene: ROBO4 roundabout homolog 4, magic roundabout (Drosophila).

[edit] Further reading

Schmucker D (2003). "Downstream of guidance receptors: entering the baroque period of axon guidance signaling.". Neuron 40 (1): 4–6. PMID 14527427.
Huminiecki L, Bicknell R (2001). "In silico cloning of novel endothelial-specific genes.". Genome Res. 10 (11): 1796–806. PMID 11076864.
Huminiecki L, Gorn M, Suchting S, et al. (2002). "Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis.". Genomics 79 (4): 547–52. doi:10.1006/geno.2002.6745. PMID 11944987.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Park KW, Morrison CM, Sorensen LK, et al. (2003). "Robo4 is a vascular-specific receptor that inhibits endothelial migration.". Dev. Biol. 261 (1): 251–67. PMID 12941633.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Bedell VM, Yeo SY, Park KW, et al. (2005). "roundabout4 is essential for angiogenesis in vivo.". Proc. Natl. Acad. Sci. U.S.A. 102 (18): 6373–8. doi:10.1073/pnas.0408318102. PMID 15849270.
Seth P, Lin Y, Hanai J, et al. (2005). "Magic roundabout, a tumor endothelial marker: expression and signaling.". Biochem. Biophys. Res. Commun. 332 (2): 533–41. doi:10.1016/j.bbrc.2005.03.250. PMID 15894287.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.
Gröne J, Doebler O, Loddenkemper C, et al. (2007). "Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer.". Oncol. Rep. 15 (6): 1437–43. PMID 16685377.
Okada Y, Yano K, Jin E, et al. (2007). "A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium.". Circ. Res. 100 (12): 1712–22. doi:10.1161/01.RES.0000269779.10644.dc. PMID 17495228.