ROBO3

From Wikipedia, the free encyclopedia

Roundabout, axon guidance receptor, homolog 3 (Drosophila)

Identifiers

ROBO3; RIG1; FLJ21044; HGPPS; RBIG1

External IDs

OMIM: 608630 MGI: 1343102 HomoloGene: 32119

Gene ontology
Molecular Function:	• receptor activity • protein binding • protein homodimerization activity • protein heterodimerization activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• neuron migration • chemotaxis • multicellular organismal development • nervous system development • axon guidance • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_022370 (mRNA)
NP_071765 (protein)

NM_011248 (mRNA)
NP_035378 (protein)

Location

Chr 11: 124.24 - 124.26 Mb

n/a

Pubmed search

[1]

[2]

Roundabout, axon guidance receptor, homolog 3 (Drosophila), also known as ROBO3, is a human gene.^[1]

[edit] References

^ Entrez Gene: ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila).

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Yuan SS, Cox LA, Dasika GK, Lee EY (1999). "Cloning and functional studies of a novel gene aberrantly expressed in RB-deficient embryos.". Dev. Biol. 207 (1): 62–75. doi:10.1006/dbio.1998.9141. PMID 10049565.
Jen J, Coulin CJ, Bosley TM, et al. (2002). "Familial horizontal gaze palsy with progressive scoliosis maps to chromosome 11q23-25.". Neurology 59 (3): 432–5. PMID 12177379.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Jen JC, Chan WM, Bosley TM, et al. (2004). "Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis.". Science 304 (5676): 1509–13. doi:10.1126/science.1096437. PMID 15105459.
Bosley TM, Salih MA, Jen JC, et al. (2006). "Neurologic features of horizontal gaze palsy and progressive scoliosis with mutations in ROBO3.". Neurology 64 (7): 1196–203. doi:10.1212/01.WNL.0000156349.01765.2B. PMID 15824346.
Camurri L, Mambetisaeva E, Davies D, et al. (2006). "Evidence for the existence of two Robo3 isoforms with divergent biochemical properties.". Mol. Cell. Neurosci. 30 (4): 485–93. doi:10.1016/j.mcn.2005.07.014. PMID 16226035.
Chan WM, Traboulsi EI, Arthur B, et al. (2006). "Horizontal gaze palsy with progressive scoliosis can result from compound heterozygous mutations in ROBO3.". J. Med. Genet. 43 (3): e11. doi:10.1136/jmg.2005.035436. PMID 16525029.