ROBO2

From Wikipedia, the free encyclopedia

Roundabout, axon guidance receptor, homolog 2 (Drosophila)

PDB rendering based on 1uem.

Available structures: 1uem, 1ujt

Identifiers

Symbol(s)

ROBO2; KIAA1568

External IDs

OMIM: 602431 MGI: 1890110 HomoloGene: 43188

Gene ontology
Molecular Function:	• axon guidance receptor activity • identical protein binding • protein heterodimerization activity
Cellular Component:	• cell surface • integral to membrane • axolemma
Biological Process:	• ureteric bud development • chemotaxis • cell adhesion • homophilic cell adhesion • multicellular organismal development • axon guidance • brain development • cell differentiation • positive regulation of axonogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_002942 (mRNA)
NP_002933 (protein)

NM_175549 (mRNA)
NP_780758 (protein)

Location

Chr 3: 77.17 - 77.78 Mb

n/a

Pubmed search

[1]

[2]

Roundabout, axon guidance receptor, homolog 2 (Drosophila), also known as ROBO2, is a human gene.^[1]

[edit] References

^ Entrez Gene: ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila).

[edit] Further reading

Kidd T, Brose K, Mitchell KJ, et al. (1998). "Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors.". Cell 92 (2): 205-15. PMID 9458045.
Brose K, Bland KS, Wang KH, et al. (1999). "Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance.". Cell 96 (6): 795-806. PMID 10102268.
Nguyen Ba-Charvet KT, Brose K, Marillat V, et al. (1999). "Slit2-Mediated chemorepulsion and collapse of developing forebrain axons.". Neuron 22 (3): 463-73. PMID 10197527.
Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (4): 273-81. PMID 10997877.
Nguyen Ba-Charvet KT, Brose K, Ma L, et al. (2001). "Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance.". J. Neurosci. 21 (12): 4281-9. PMID 11404413.
Marillat V, Cases O, Nguyen-Ba-Charvet KT, et al. (2002). "Spatiotemporal expression patterns of slit and robo genes in the rat brain.". J. Comp. Neurol. 442 (2): 130-55. PMID 11754167.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Hivert B, Liu Z, Chuang CY, et al. (2003). "Robo1 and Robo2 are homophilic binding molecules that promote axonal growth.". Mol. Cell. Neurosci. 21 (4): 534-45. PMID 12504588.
Grieshammer U, Le Ma , Plump AS, et al. (2004). "SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site.". Dev. Cell 6 (5): 709-17. PMID 15130495.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Yue Y, Grossmann B, Galetzka D, et al. (2007). "Isolation and differential expression of two isoforms of the ROBO2/Robo2 axon guidance receptor gene in humans and mice.". Genomics 88 (6): 772-8. doi:10.1016/j.ygeno.2006.05.011. PMID 16829019.
Lu W, van Eerde AM, Fan X, et al. (2007). "Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux.". Am. J. Hum. Genet. 80 (4): 616-32. doi:10.1086/512735. PMID 17357069.