RNPEP

From Wikipedia, the free encyclopedia

Arginyl aminopeptidase (aminopeptidase B)

Identifiers

RNPEP; DKFZP547H084

External IDs

OMIM: 602675 MGI: 2384902 HomoloGene: 10628

Gene ontology
Molecular Function:	• membrane alanyl aminopeptidase activity • epoxide hydrolase activity • zinc ion binding • aminopeptidase B activity • metal ion binding
Cellular Component:	• extracellular region • Golgi apparatus • plasma membrane
Biological Process:	• proteolysis • protein processing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_020216 (mRNA)
NP_064601 (protein)

NM_145417 (mRNA)
NP_663392 (protein)

Location

Chr 1: 200.22 - 200.24 Mb

Chr 1: 137.08 - 137.1 Mb

Pubmed search

[1]

[2]

Arginyl aminopeptidase (aminopeptidase B), also known as RNPEP, is a human gene.^[1]

[edit] References

^ Entrez Gene: RNPEP arginyl aminopeptidase (aminopeptidase B).

[edit] Further reading

Foulon T, Cadel S, Cohen P (1999). "Aminopeptidase B (EC 3.4.11.6).". Int. J. Biochem. Cell Biol. 31 (7): 747–50. PMID 10467730.
Belhacene N, Mari B, Rossi B, Auberger P (1993). "Characterization and purification of T lymphocyte aminopeptidase B: a putative marker of T cell activation.". Eur. J. Immunol. 23 (8): 1948–55. PMID 8344358.
Gress TM, Müller-Pillasch F, Geng M, et al. (1996). "A pancreatic cancer-specific expression profile.". Oncogene 13 (8): 1819–30. PMID 8895530.
Balogh A, Cadel S, Foulon T, et al. (1998). "Aminopeptidase B: a processing enzyme secreted and associated with the plasma membrane of rat pheochromocytoma (PC12) cells.". J. Cell. Sci. 111 ( Pt 2): 161–9. PMID 9405297.
Aurich-Costa J, Cadel S, Gouzy C, et al. (1998). "Assignment of the aminopeptidase B gene (RNPEP) to human chromosome 1 band q32 by in situ hybridization.". Cytogenet. Cell Genet. 79 (1-2): 143–4. PMID 9533033.
Piesse C, Tymms M, Garrafa E, et al. (2002). "Human aminopeptidase B (rnpep) on chromosome 1q32.2: complementary DNA, genomic structure and expression.". Gene 292 (1-2): 129–40. PMID 12119107.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Fukasawa KM, Hirose J, Hata T, Ono Y (2006). "Aspartic acid 405 contributes to the substrate specificity of aminopeptidase B.". Biochemistry 45 (38): 11425–31. doi:10.1021/bi0604577. PMID 16981702.