RNMT

From Wikipedia, the free encyclopedia

RNA (guanine-7-) methyltransferase

Identifiers

RNMT; MET; DKFZp686H1252; KIAA0398; RG7MT1; hCMT1c

External IDs

OMIM: 603514 MGI: 1915147 HomoloGene: 2816

Gene ontology
Molecular Function:	• RNA binding • mRNA (guanine-N7-)-methyltransferase activity • methyltransferase activity • transferase activity
Cellular Component:	• nucleus
Biological Process:	• mRNA capping

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003799 (mRNA)
NP_003790 (protein)

NM_026440 (mRNA)
NP_080716 (protein)

Location

Chr 18: 13.72 - 13.75 Mb

Chr 18: 68.43 - 68.45 Mb

Pubmed search

[1]

[2]

RNA (guanine-7-) methyltransferase, also known as RNMT, is a human gene.^[1]

[edit] References

^ Entrez Gene: RNMT RNA (guanine-7-) methyltransferase.

[edit] Further reading

Langberg SR, Moss B (1981). "Post-transcriptional modifications of mRNA. Purification and characterization of cap I and cap II RNA (nucleoside-2'-)-methyltransferases from HeLa cells.". J. Biol. Chem. 256 (19): 10054–60. PMID 7275966.
Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 4 (5): 307–13. PMID 9455477.
Pillutla RC, Yue Z, Maldonado E, Shatkin AJ (1998). "Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes.". J. Biol. Chem. 273 (34): 21443–6. PMID 9705270.
Tsukamoto T, Shibagaki Y, Niikura Y, Mizumoto K (1998). "Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)-methyltransferase, an mRNA cap methylase.". Biochem. Biophys. Res. Commun. 251 (1): 27–34. doi:10.1006/bbrc.1998.9402. PMID 9790902.
Pillutla RC, Shimamoto A, Furuichi Y, Shatkin AJ (1999). "Human mRNA capping enzyme (RNGTT) and cap methyltransferase (RNMT) map to 6q16 and 18p11.22-p11.23, respectively.". Genomics 54 (2): 351–3. doi:10.1006/geno.1998.5604. PMID 9828141.
Saha N, Schwer B, Shuman S (1999). "Characterization of human, Schizosaccharomyces pombe, and Candida albicans mRNA cap methyltransferases and complete replacement of the yeast capping apparatus by mammalian enzymes.". J. Biol. Chem. 274 (23): 16553–62. PMID 10347220.
Yamada-Okabe T, Mio T, Kashima Y, et al. (2000). "The Candida albicans gene for mRNA 5-cap methyltransferase: identification of additional residues essential for catalysis.". Microbiology (Reading, Engl.) 145 ( Pt 11): 3023–33. PMID 10589710.
Wen Y, Shatkin AJ (2001). "Cap methyltransferase selective binding and methylation of GpppG-RNA are stimulated by importin-alpha.". Genes Dev. 14 (23): 2944–9. PMID 11114884.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Shafer B, Chu C, Shatkin AJ (2005). "Human mRNA cap methyltransferase: alternative nuclear localization signal motifs ensure nuclear localization required for viability.". Mol. Cell. Biol. 25 (7): 2644–9. doi:10.1128/MCB.25.7.2644-2649.2005. PMID 15767670.