RNF5

From Wikipedia, the free encyclopedia

Ring finger protein 5

Identifiers

RNF5; RING5; RMA1

External IDs

OMIM: 602677 MGI: 1860076 HomoloGene: 56004

Gene ontology
Molecular Function:	• protein binding • zinc ion binding • ligase activity • metal ion binding
Cellular Component:	• membrane • integral to membrane
Biological Process:	• ubiquitin cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006913 (mRNA)
NP_008844 (protein)

NM_019403 (mRNA)
NP_062276 (protein)

Location

Chr c6_QBL: 32.25 - 32.25 Mb

Chr 17: 34.21 - 34.21 Mb

Pubmed search

[1]

[2]

Ring finger protein 5, also known as RNF5, is a human gene.^[1]

The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

RING finger domain

[edit] References

^ ^a ^b Entrez Gene: RNF5 ring finger protein 5.

[edit] Further reading

Kendall E, Sargent CA, Campbell RD (1991). "Human major histocompatibility complex contains a new cluster of genes between the HLA-D and complement C4 loci.". Nucleic Acids Res. 18 (24): 7251–7. PMID 2259622.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Kyushiki H, Kuga Y, Suzuki M, et al. (1998). "Cloning, expression and mapping of a novel RING-finger gene (RNF5), a human homologue of a putative zinc-finger gene from Caenorhabditis elegans.". Cytogenet. Cell Genet. 79 (1-2): 114–7. PMID 9533025.
Barritt DS, Pearn MT, Zisch AH, et al. (2000). "The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2.". J. Cell. Biochem. 79 (2): 213–24. PMID 10967549.
Matsuda N, Suzuki T, Tanaka K, Nakano A (2001). "Rma1, a novel type of RING finger protein conserved from Arabidopsis to human, is a membrane-bound ubiquitin ligase.". J. Cell. Sci. 114 (Pt 10): 1949–57. PMID 11329381.
Pouly S, Prat A, Blain M, et al. (2002). "NG2 immunoreactivity on human brain endothelial cells.". Acta Neuropathol. 102 (4): 313–20. PMID 11603805.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Didier C, Broday L, Bhoumik A, et al. (2003). "RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization.". Mol. Cell. Biol. 23 (15): 5331–45. PMID 12861019.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMID 14656967.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153–67. PMID 14667819.
Liu AM, Wong YH (2005). "G16-mediated activation of nuclear factor kappaB by the adenosine A1 receptor involves c-Src, protein kinase C, and ERK signaling.". J. Biol. Chem. 279 (51): 53196–204. doi:10.1074/jbc.M410196200. PMID 15485865.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Zhang Y, Higashide W, Dai S, et al. (2006). "Recognition and ubiquitination of Salmonella type III effector SopA by a ubiquitin E3 ligase, HsRMA1.". J. Biol. Chem. 280 (46): 38682–8. doi:10.1074/jbc.M506309200. PMID 16176924.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Younger JM, Chen L, Ren HY, et al. (2006). "Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator.". Cell 126 (3): 571–82. doi:10.1016/j.cell.2006.06.041. PMID 16901789.
Bromberg KD, Kluger HM, Delaunay A, et al. (2007). "Increased expression of the E3 ubiquitin ligase RNF5 is associated with decreased survival in breast cancer.". Cancer Res. 67 (17): 8172–9. doi:10.1158/0008-5472.CAN-07-0045. PMID 17804730.