RNF4

From Wikipedia, the free encyclopedia

Ring finger protein 4

Identifiers

RNF4; RES4-26; SNURF

External IDs

OMIM: 602850 MGI: 1201691 HomoloGene: 37711

Gene ontology
Molecular Function:	• transcription factor activity • transcription coactivator activity • protein binding • zinc ion binding • metal ion binding • androgen receptor binding
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription from RNA polymerase II promoter • androgen receptor signaling pathway • positive regulation of transcription, DNA-dependent

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_002938 (mRNA)
NP_002929 (protein)

NM_011278 (mRNA)
NP_035408 (protein)

Location

n/a

Chr 5: 34.66 - 34.67 Mb

Pubmed search

[1]

[2]

Ring finger protein 4, also known as RNF4, is a human gene.^[1]

The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

RING finger domain

[edit] References

^ ^a ^b Entrez Gene: RNF4 ring finger protein 4.

[edit] Further reading

Chiariotti L, Benvenuto G, Fedele M, et al. (1998). "Identification and characterization of a novel RING-finger gene (RNF4) mapping at 4p16.3.". Genomics 47 (2): 258–65. doi:10.1006/geno.1997.5105. PMID 9479498.
Moilanen AM, Poukka H, Karvonen U, et al. (1998). "Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription.". Mol. Cell. Biol. 18 (9): 5128–39. PMID 9710597.
Hadano S, Ishida Y, Ikeda JE (1998). "The primary structure and genomic organization of five novel transcripts located close to the Huntington's disease gene on human chromosome 4p16.3.". DNA Res. 5 (3): 177–86. PMID 9734812.
Poukka H, Aarnisalo P, Santti H, et al. (2000). "Coregulator small nuclear RING finger protein (SNURF) enhances Sp1- and steroid receptor-mediated transcription by different mechanisms.". J. Biol. Chem. 275 (1): 571–9. PMID 10617653.
Fedele M, Benvenuto G, Pero R, et al. (2000). "A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor.". J. Biol. Chem. 275 (11): 7894–901. PMID 10713105.
Galili N, Nayak S, Epstein JA, Buck CA (2000). "Rnf4, a RING protein expressed in the developing nervous and reproductive systems, interacts with Gscl, a gene within the DiGeorge critical region.". Dev. Dyn. 218 (1): 102–11. doi:10.1002/(SICI)1097-0177(200005)218:1<102::AID-DVDY9>3.0.CO;2-A. PMID 10822263.
Lyngsø C, Bouteiller G, Damgaard CK, et al. (2000). "Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers.". J. Biol. Chem. 275 (34): 26144–9. doi:10.1074/jbc.M003405200. PMID 10849425.
Häkli M, Karvonen U, Jänne OA, Palvimo JJ (2001). "The RING finger protein SNURF is a bifunctional protein possessing DNA binding activity.". J. Biol. Chem. 276 (26): 23653–60. doi:10.1074/jbc.M009891200. PMID 11319220.
Saville B, Poukka H, Wormke M, et al. (2002). "Cooperative coactivation of estrogen receptor alpha in ZR-75 human breast cancer cells by SNURF and TATA-binding protein.". J. Biol. Chem. 277 (4): 2485–97. doi:10.1074/jbc.M109021200. PMID 11696545.
Pero R, Lembo F, Palmieri EA, et al. (2002). "PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription.". J. Biol. Chem. 277 (5): 3280–5. doi:10.1074/jbc.M109491200. PMID 11719514.
Yan W, Hirvonen-Santti SJ, Palvimo JJ, et al. (2003). "Expression of the nuclear RING finger protein SNURF/RNF4 during rat testis development suggests a role in spermatid maturation.". Mech. Dev. 118 (1-2): 247–53. PMID 12351196.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Pero R, Lembo F, Chieffi P, et al. (2004). "Translational regulation of a novel testis-specific RNF4 transcript.". Mol. Reprod. Dev. 66 (1): 1–7. doi:10.1002/mrd.10322. PMID 12874792.
Kaiser FJ, Möröy T, Chang GT, et al. (2003). "The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor.". J. Biol. Chem. 278 (40): 38780–5. doi:10.1074/jbc.M306259200. PMID 12885770.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Lin DY, Fang HI, Ma AH, et al. (2004). "Negative modulation of androgen receptor transcriptional activity by Daxx.". Mol. Cell. Biol. 24 (24): 10529–41. doi:10.1128/MCB.24.24.10529-10541.2004. PMID 15572661.