RNF41

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Ring finger protein 41
PDB rendering based on 2fzp.
Available structures: 2fzp, 2gwf, 2ogb
Identifiers
Symbol(s) RNF41; MGC45228; NRDP1; SBBI03
External IDs MGI: 1914838 HomoloGene: 4226
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10193 67588
Ensembl ENSG00000181852 ENSMUSG00000025373
Uniprot Q9H4P4 Q99MS2
Refseq NM_005785 (mRNA)
NP_005776 (protein)		 NM_026259 (mRNA)
NP_080535 (protein)
Location Chr 12: 54.88 - 54.9 Mb Chr 10: 127.81 - 127.84 Mb
Pubmed search [1] [2]

Ring finger protein 41, also known as RNF41, is a human gene.[1]

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The specific function of this protein has not yet been determined. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.[1]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: RNF41 ring finger protein 41.

[edit] Further reading

  • Cao Z, Wu X, Yen L, et al. (2007). "Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1.". Mol. Cell. Biol. 27 (6): 2180–8. doi:10.1128/MCB.01245-06. PMID 17210635. 
  • Avvakumov GV, Walker JR, Xue S, et al. (2007). "Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8).". J. Biol. Chem. 281 (49): 38061–70. doi:10.1074/jbc.M606704200. PMID 17035239. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wu X, Yen L, Irwin L, et al. (2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8.". Mol. Cell. Biol. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMID 15314180. 
  • Qiu XB, Markant SL, Yuan J, Goldberg AL (2005). "Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis.". EMBO J. 23 (4): 800–10. doi:10.1038/sj.emboj.7600075. PMID 14765125. 
  • Brajenovic M, Joberty G, Küster B, et al. (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Qiu XB, Goldberg AL (2003). "Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3.". Proc. Natl. Acad. Sci. U.S.A. 99 (23): 14843–8. doi:10.1073/pnas.232580999. PMID 12411582. 
  • Diamonti AJ, Guy PM, Ivanof C, et al. (2002). "An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels.". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2866–71. doi:10.1073/pnas.052709799. PMID 11867753. 
  • Abdullah JM, Li X, Nachtman RG, Jurecic R (2001). "FLRF, a novel evolutionarily conserved RING finger gene, is differentially expressed in mouse fetal and adult hematopoietic stem cells and progenitors.". Blood Cells Mol. Dis. 27 (1): 320–33. doi:10.1006/bcmd.2001.0390. PMID 11358394. 
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174. 
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 

[edit] External links

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