RNF40

From Wikipedia, the free encyclopedia

Ring finger protein 40

Identifiers

RNF40; BRE1B; DKFZp686K191; KIAA0661; MGC13051; RBP95; STARING

External IDs

OMIM: 607700 MGI: 2142048 HomoloGene: 8856

Gene ontology
Molecular Function:	• protein binding • zinc ion binding • ligase activity • metal ion binding
Cellular Component:	• nucleus • chromosome
Biological Process:	• ubiquitin cycle • chromatin modification

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014771 (mRNA)
NP_055586 (protein)

NM_172281 (mRNA)
NP_758485 (protein)

Location

Chr 16: 30.68 - 30.69 Mb

Chr 7: 127.38 - 127.39 Mb

Pubmed search

[1]

[2]

Ring finger protein 40, also known as RNF40, is a human gene.^[1]

The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery.^[1]

[edit] References

^ ^a ^b Entrez Gene: RNF40 ring finger protein 40.

[edit] Further reading

Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169–76. PMID 9734811.
Wen H, Ao S (2000). "RBP95, a novel leucine zipper protein, binds to the retinoblastoma protein.". Biochem. Biophys. Res. Commun. 275 (1): 141–8. doi:10.1006/bbrc.2000.3242. PMID 10944455.
Chin LS, Vavalle JP, Li L (2002). "Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation.". J. Biol. Chem. 277 (38): 35071–9. doi:10.1074/jbc.M203300200. PMID 12121982.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Zhu B, Zheng Y, Pham AD, et al. (2006). "Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation.". Mol. Cell 20 (4): 601–11. doi:10.1016/j.molcel.2005.09.025. PMID 16307923.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.