RNF25

From Wikipedia, the free encyclopedia

Ring finger protein 25

PDB rendering based on 2day.

Available structures: 2day, 2dmf

Identifiers

Symbol(s)

RNF25; AO7; FLJ13906

External IDs

MGI: 1890215 HomoloGene: 11193

Gene ontology
Molecular Function:	• ubiquitin-protein ligase activity • protein binding • zinc ion binding • ligase activity • metal ion binding
Biological Process:	• ubiquitin cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_022453 (mRNA)
NP_071898 (protein)

NM_021313 (mRNA)
NP_067288 (protein)

Location

Chr 2: 219.24 - 219.25 Mb

Chr 1: 74.53 - 74.53 Mb

Pubmed search

[1]

[2]

Ring finger protein 25, also known as RNF25, is a human gene.^[1]

The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination.^[1]

[edit] References

^ ^a ^b Entrez Gene: RNF25 ring finger protein 25.

[edit] Further reading

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Asamitsu K, Tetsuka T, Kanazawa S, Okamoto T (2003). "RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit.". J. Biol. Chem. 278 (29): 26879-87. doi:10.1074/jbc.M211831200. PMID 12748188.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Lorick KL, Jensen JP, Fang S, et al. (1999). "RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11364-9. PMID 10500182.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.