RNF216

From Wikipedia, the free encyclopedia

TRIAD3 protein

Identifiers

TRIAD3; ZIN; U7I1; UBCE7IP1

External IDs

OMIM: 609948 MGI: 1344349 HomoloGene: 19442

Gene ontology
Molecular Function:	• protein binding • zinc ion binding • ligase activity • metal ion binding • hydrogen ion transporting ATP synthase activity, rotational mechanism • hydrogen ion transporting ATPase activity, rotational mechanism
Cellular Component:	• nucleus • proton-transporting two-sector ATPase complex
Biological Process:	• ubiquitin cycle • apoptosis • ATP synthesis coupled proton transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_207111 (mRNA)
NP_996994 (protein)

XM_981910 (mRNA)
XP_987004 (protein)

Location

Chr 7: 5.63 - 5.79 Mb

Chr 5: 143.26 - 143.38 Mb

Pubmed search

[1]

[2]

TRIAD3 protein, also known as TRIAD3, is a human gene.^[1]

This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

RING finger domain

[edit] References

^ ^a ^b Entrez Gene: TRIAD3 TRIAD3 protein.

[edit] Further reading

Lake JA, Carr J, Feng F, et al. (2003). "The role of Vif during HIV-1 infection: interaction with novel host cellular factors.". J. Clin. Virol. 26 (2): 143-52. PMID 12600646.
Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression.". Gene 146 (2): 199-207. PMID 8076819.
van der Reijden BA, Erpelinck-Verschueren CA, Löwenberg B, Jansen JH (1999). "TRIADs: a new class of proteins with a novel cysteine-rich signature.". Protein Sci. 8 (7): 1557-61. PMID 10422847.
Wang X, Stollar BD (1999). "Immunoglobulin VH gene expression in human aging.". Clin. Immunol. 93 (2): 132-42. doi:10.1006/clim.1999.4781. PMID 10527689.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Chen D, Li X, Zhai Z, Shu HB (2002). "A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation.". J. Biol. Chem. 277 (18): 15985-91. doi:10.1074/jbc.M108675200. PMID 11854271.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157-64. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Chuang TH, Ulevitch RJ (2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors.". Nat. Immunol. 5 (5): 495-502. doi:10.1038/ni1066. PMID 15107846.
Feng F, Davis A, Lake JA, et al. (2004). "Ring finger protein ZIN interacts with human immunodeficiency virus type 1 Vif.". J. Virol. 78 (19): 10574-81. doi:10.1128/JVI.78.19.10574-10581.2004. PMID 15367624.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942-54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
Fearns C, Pan Q, Mathison JC, Chuang TH (2006). "Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding.". J. Biol. Chem. 281 (45): 34592-600. doi:10.1074/jbc.M604019200. PMID 16968706.