RNF20

From Wikipedia, the free encyclopedia

Ring finger protein 20

Identifiers

RNF20; BRE1A; FLJ11189; FLJ20382; KIAA2779; MGC129667; MGC129668

External IDs

OMIM: 607699 MGI: 1925927 HomoloGene: 5571

Gene ontology
Molecular Function:	• protein binding • zinc ion binding • ligase activity • metal ion binding
Cellular Component:	• nucleus • chromosome
Biological Process:	• ubiquitin cycle • chromatin modification

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_019592 (mRNA)
NP_062538 (protein)

NM_182999 (mRNA)
NP_892044 (protein)

Location

Chr 9: 103.34 - 103.37 Mb

Chr 4: 49.65 - 49.68 Mb

Pubmed search

[1]

[2]

Ring finger protein 20, also known as RNF20, is a human gene.^[1]

The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. Yeast BRE1 is a ubiquitin ligase required for the ubiquitination of histone H2B and the methylation of histone H3.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

RING finger domain

[edit] References

^ ^a ^b Entrez Gene: RNF20 ring finger protein 20.

[edit] Further reading

Lossos IS, Alizadeh AA, Eisen MB, et al. (2000). "Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas.". Proc. Natl. Acad. Sci. U.S.A. 97 (18): 10209–13. doi:10.1073/pnas.180316097. PMID 10954754.
Slachta CA, Jeevanandam V, Goldman B, et al. (2000). "Coronary arteries from human cardiac allografts with chronic rejection contain oligoclonal T cells: persistence of identical clonally expanded TCR transcripts from the early post-transplantation period (endomyocardial biopsies) to chronic rejection (coronary arteries).". J. Immunol. 165 (6): 3469–83. PMID 10975868.
Lee J, Monson NL, Lipsky PE (2001). "The V lambda J lambda repertoire in human fetal spleen: evidence for positive selection and extensive receptor editing.". J. Immunol. 165 (11): 6322–33. PMID 11086069.
Rowley AH, Shulman ST, Spike BT, et al. (2001). "Oligoclonal IgA response in the vascular wall in acute Kawasaki disease.". J. Immunol. 166 (2): 1334–43. PMID 11145718.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hwang WW, Venkatasubrahmanyam S, Ianculescu AG, et al. (2003). "A conserved RING finger protein required for histone H2B monoubiquitination and cell size control.". Mol. Cell 11 (1): 261–6. PMID 12535538.
Wood A, Krogan NJ, Dover J, et al. (2003). "Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter.". Mol. Cell 11 (1): 267–74. PMID 12535539.
Wood A, Schneider J, Dover J, et al. (2003). "The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p.". J. Biol. Chem. 278 (37): 34739–42. doi:10.1074/jbc.C300269200. PMID 12876294.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Zhu B, Zheng Y, Pham AD, et al. (2006). "Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation.". Mol. Cell 20 (4): 601–11. doi:10.1016/j.molcel.2005.09.025. PMID 16307923.
Kim J, Hake SB, Roeder RG (2006). "The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions.". Mol. Cell 20 (5): 759–70. doi:10.1016/j.molcel.2005.11.012. PMID 16337599.