RNF14

From Wikipedia, the free encyclopedia

Ring finger protein 14
Identifiers
Symbol(s) RNF14; ARA54; FLJ26004; HFB30; HRIHFB2038
External IDs OMIM: 605675 MGI: 1929668 HomoloGene: 6573
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9604 56736
Ensembl ENSG00000013561 ENSMUSG00000060450
Uniprot Q9UBS8 Q7TPR0
Refseq NM_004290 (mRNA)
NP_004281 (protein)		 NM_020012 (mRNA)
NP_064396 (protein)
Location Chr 5: 141.33 - 141.35 Mb Chr 18: 38.42 - 38.44 Mb
Pubmed search [1] [2]

Ring finger protein 14, also known as RNF14, is a human gene.[1]

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Five alternatively spliced transcript variants encoding two distinct isoforms have been reported.[1]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: RNF14 ring finger protein 14.

[edit] Further reading

  • Ueki N, Oda T, Kondo M, et al. (1999). "Selection system for genes encoding nuclear-targeted proteins.". Nat. Biotechnol. 16 (13): 1338–42. doi:10.1038/4315. PMID 9853615. 
  • Kang HY, Yeh S, Fujimoto N, Chang C (1999). "Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor.". J. Biol. Chem. 274 (13): 8570–6. PMID 10085091. 
  • Ueki N, Seki N, Yano K, et al. (1999). "Isolation and characterization of a novel human gene (HFB30) which encodes a protein with a RING finger motif.". Biochim. Biophys. Acta 1445 (2): 232–6. PMID 10320776. 
  • Ito K, Adachi S, Iwakami R, et al. (2001). "N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8.". Eur. J. Biochem. 268 (9): 2725–32. PMID 11322894. 
  • Miyamoto H, Rahman M, Takatera H, et al. (2002). "A dominant-negative mutant of androgen receptor coregulator ARA54 inhibits androgen receptor-mediated prostate cancer growth.". J. Biol. Chem. 277 (7): 4609–17. doi:10.1074/jbc.M108312200. PMID 11673464. 
  • Ueda T, Mawji NR, Bruchovsky N, Sadar MD (2002). "Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells.". J. Biol. Chem. 277 (41): 38087–94. doi:10.1074/jbc.M203313200. PMID 12163482. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • He B, Wilson EM (2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs.". Mol. Cell. Biol. 23 (6): 2135–50. PMID 12612084. 
  • Mestayer C, Blanchère M, Jaubert F, et al. (2003). "Expression of androgen receptor coactivators in normal and cancer prostate tissues and cultured cell lines.". Prostate 56 (3): 192–200. doi:10.1002/pros.10229. PMID 12772188. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Wang L, Hsu CL, Ni J, et al. (2004). "Human checkpoint protein hRad9 functions as a negative coregulator to repress androgen receptor transactivation in prostate cancer cells.". Mol. Cell. Biol. 24 (5): 2202–13. PMID 14966297. 
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Lin DY, Fang HI, Ma AH, et al. (2004). "Negative modulation of androgen receptor transcriptional activity by Daxx.". Mol. Cell. Biol. 24 (24): 10529–41. doi:10.1128/MCB.24.24.10529-10541.2004. PMID 15572661. 
  • Yang Z, Chang YJ, Miyamoto H, et al. (2007). "Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth.". Mol. Endocrinol. 21 (2): 343–58. doi:10.1210/me.2006-0104. PMID 17082327. 
  • Yang Z, Chang YJ, Miyamoto H, et al. (2007). "Suppression of androgen receptor transactivation and prostate cancer cell growth by heterogeneous nuclear ribonucleoprotein A1 via interaction with androgen receptor coregulator ARA54.". Endocrinology 148 (3): 1340–9. doi:10.1210/en.2006-0716. PMID 17110431. 
  • Kikuchi H, Uchida C, Hattori T, et al. (2007). "ARA54 is involved in transcriptional regulation of the cyclin D1 gene in human cancer cells.". Carcinogenesis 28 (8): 1752–8. doi:10.1093/carcin/bgm120. PMID 17510080. 

[edit] External links

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v • d • e
Transcription coregulators
Coactivators
ARA54 - ARA55 - CARM1 - CRTC1 - CRTC2 - CBP - PPARGC1A - PPARGC1B - TGFB1I1
NCOA1 (SRC-1) - NCOA2 (GRIP1/SRC-2/TIF2) - NCOA3 (AIB/SRC-3/TRAM-1) - NCOA4 (ARA70) - NCOA5 (CIA) - NCOA6 (RAP250) - NCOA7 (ERAP140)
Corepressors
Hairless homolog - NRIP1 - PELP-1 - RCOR1 - Rb - SIN3A - SIN3B - Tripartite motif-containing (TRIM24, TRIM28, TRIM33)
NCOR1 - NCOR2 (SMRT)
ATP-dependent remodeling factors