RNF139

From Wikipedia, the free encyclopedia

Ring finger protein 139

Identifiers

RNF139; HRCA1; RCA1; MGC31961; TRC8

External IDs

OMIM: 603046 MGI: 1923091 HomoloGene: 5222

Gene ontology
Molecular Function:	• receptor activity • protein binding • zinc ion binding • ligase activity • metal ion binding
Cellular Component:	• endoplasmic reticulum • membrane • integral to membrane
Biological Process:	• ubiquitin cycle • regulation of protein ubiquitination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007218 (mRNA)
NP_009149 (protein)

NM_175226 (mRNA)
NP_780435 (protein)

Location

Chr 8: 125.56 - 125.57 Mb

Chr 15: 58.72 - 58.73 Mb

Pubmed search

[1]

[2]

Ring finger protein 139, also known as RNF139, is a human gene.^[1]

The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.^[1]

[edit] References

^ ^a ^b Entrez Gene: RNF139 ring finger protein 139.

[edit] Further reading

Poland KS, Azim M, Folsom M, et al. (2007). "A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma.". Genes Chromosomes Cancer 46 (9): 805–12. doi:10.1002/gcc.20466. PMID 17539022.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Brauweiler A, Lorick KL, Lee JP, et al. (2007). "RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene.". Oncogene 26 (16): 2263–71. doi:10.1038/sj.onc.1210017. PMID 17016439.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gemmill RM, Bemis LT, Lee JP, et al. (2002). "The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway.". Oncogene 21 (22): 3507–16. doi:10.1038/sj.onc.1205437. PMID 12032852.
Lorick KL, Jensen JP, Fang S, et al. (1999). "RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11364–9. PMID 10500182.
Gemmill RM, West JD, Boldog F, et al. (1998). "The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8.". Proc. Natl. Acad. Sci. U.S.A. 95 (16): 9572–7. PMID 9689122.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.