RNF128

From Wikipedia, the free encyclopedia

Ring finger protein 128

Identifiers

RNF128; FLJ23516; GRAIL

External IDs

OMIM: 300439 MGI: 1914139 HomoloGene: 11337

Gene ontology
Molecular Function:	• protein binding • peptidase activity • zinc ion binding • ligase activity • metal ion binding
Cellular Component:	• membrane • integral to membrane
Biological Process:	• proteolysis • ubiquitin cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_024539 (mRNA)
NP_078815 (protein)

NM_023270 (mRNA)
NP_075759 (protein)

Location

Chr X: 105.82 - 105.93 Mb

Chr X: 134.96 - 135.02 Mb

Pubmed search

[1]

[2]

Ring finger protein 128, also known as RNF128, is a human gene.^[1]

The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported.^[1]

[edit] References

^ ^a ^b Entrez Gene: RNF128 ring finger protein 128.

[edit] Further reading

Kostianovsky AM, Maier LM, Baecher-Allan C, et al. (2007). "Up-regulation of gene related to anergy in lymphocytes is associated with Notch-mediated human T cell suppression.". J. Immunol. 178 (10): 6158-63. PMID 17475842.
MacKenzie DA, Schartner J, Lin J, et al. (2007). "GRAIL is up-regulated in CD4+ CD25+ T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype.". J. Biol. Chem. 282 (13): 9696-702. doi:10.1074/jbc.M604192200. PMID 17259178.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325-37. doi:10.1038/nature03440. PMID 15772651.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Soares L, Seroogy C, Skrenta H, et al. (2004). "Two isoforms of otubain 1 regulate T cell anergy via GRAIL.". Nat. Immunol. 5 (1): 45-54. doi:10.1038/ni1017. PMID 14661020.
Anandasabapathy N, Ford GS, Bloom D, et al. (2003). "GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells.". Immunity 18 (4): 535-47. PMID 12705856.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.