RNF111

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Ring finger protein 111
Identifiers
Symbol(s) RNF111; ARK; DKFZp313E0731; DKFZp686H1966; DKFZp761D081; FLJ38008
External IDs OMIM: 605840 MGI: 1934919 HomoloGene: 9741
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 54778 93836
Ensembl ENSG00000157450 ENSMUSG00000032217
Refseq NM_017610 (mRNA)
NP_060080 (protein)		 NM_033604 (mRNA)
NP_291082 (protein)
Location Chr 15: 57.07 - 57.18 Mb Chr 9: 70.22 - 70.3 Mb
Pubmed search [1] [2]

Ring finger protein 111, also known as RNF111, is a human gene.[1]

The protein encoded by this gene contains a RING finger domain, a motif known to be involved in protein-protein and protein-DNA interactions. The mouse counterpart of this gene (Rnf111/arkadia) has been shown to genetically interact with the transforming growth factor (TGF) beta-like factor Nodal, and act as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development.[1]

[edit] References

  1. ^ a b Entrez Gene: RNF111 ring finger protein 111.

[edit] Further reading

  • Patten I, Placzek M (2001). "Vertebrate development: Et in Arkadia.". Curr. Biol. 11 (15): R616–9. PMID 11516970. 
  • Episkopou V, Arkell R, Timmons PM, et al. (2001). "Induction of the mammalian node requires Arkadia function in the extraembryonic lineages.". Nature 410 (6830): 825–30. doi:10.1038/35071095. PMID 11298452. 
  • Niederländer C, Walsh JJ, Episkopou V, Jones CM (2001). "Arkadia enhances nodal-related signalling to induce mesendoderm.". Nature 410 (6830): 830–4. doi:10.1038/35071103. PMID 11298453. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Koinuma D, Shinozaki M, Komuro A, et al. (2004). "Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7.". EMBO J. 22 (24): 6458–70. doi:10.1093/emboj/cdg632. PMID 14657019. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Liu W, Rui H, Wang J, et al. (2006). "Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.". EMBO J. 25 (8): 1646–58. doi:10.1038/sj.emboj.7601057. PMID 16601693. 
  • Nagano Y, Mavrakis KJ, Lee KL, et al. (2007). "Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling.". J. Biol. Chem. 282 (28): 20492–501. doi:10.1074/jbc.M701294200. PMID 17510063. 
  • Levy L, Howell M, Das D, et al. (2007). "Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.". Mol. Cell. Biol. 27 (17): 6068–83. doi:10.1128/MCB.00664-07. PMID 17591695. 
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