Rnd1

From Wikipedia, the free encyclopedia


Rho family GTPase 1
PDB rendering based on 2cls.
Available structures: 2cls
Identifiers
Symbol(s) RND1; ARHS; FLJ42294; RHO6
External IDs OMIM: 609038 MGI: 2444878 HomoloGene: 8706
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 27289 223881
Ensembl ENSG00000172602 ENSMUSG00000054855
Uniprot Q92730 Q8BLR7
Refseq NM_014470 (mRNA)
NP_055285 (protein)		 NM_172612 (mRNA)
NP_766200 (protein)
Location Chr 12: 47.54 - 47.55 Mb Chr 15: 98.5 - 98.51 Mb
Pubmed search [1] [2]

Rnd1 is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases.[1]. It is encoded by the gene RND1.[2]

It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM][2]


[edit] References

  1. ^ Ridley A. (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol 16 (10): 522-9. ISSN 0962-8924. 
  2. ^ a b Entrez Gene: RND1 Rho family GTPase 1.

[edit] Further reading

  • Nobes CD, Lauritzen I, Mattei MG, et al. (1998). "A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion.". J. Cell Biol. 141 (1): 187-97. PMID 9531558. 
  • Vayssière B, Zalcman G, Mahé Y, et al. (2000). "Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family.". FEBS Lett. 467 (1): 91-6. PMID 10664463. 
  • Aoki J, Katoh H, Mori K, Negishi M (2001). "Rnd1, a novel rho family GTPase, induces the formation of neuritic processes in PC12 cells.". Biochem. Biophys. Res. Commun. 278 (3): 604-8. doi:10.1006/bbrc.2000.3842. PMID 11095956. 
  • Rohm B, Rahim B, Kleiber B, et al. (2001). "The semaphorin 3A receptor may directly regulate the activity of small GTPases.". FEBS Lett. 486 (1): 68-72. PMID 11108845. 
  • Nancy V, Callebaut I, El Marjou A, de Gunzburg J (2002). "The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases.". J. Biol. Chem. 277 (17): 15076-84. doi:10.1074/jbc.M109983200. PMID 11786539. 
  • Katoh H, Harada A, Mori K, Negishi M (2002). "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers.". Mol. Cell. Biol. 22 (9): 2952-64. PMID 11940653. 
  • Hanzal-Bayer M, Renault L, Roversi P, et al. (2002). "The complex of Arl2-GTP and PDE delta: from structure to function.". EMBO J. 21 (9): 2095-106. doi:10.1093/emboj/21.9.2095. PMID 11980706. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Oinuma I, Katoh H, Harada A, Negishi M (2003). "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells.". J. Biol. Chem. 278 (28): 25671-7. doi:10.1074/jbc.M303047200. PMID 12730235. 
  • Oinuma I, Ishikawa Y, Katoh H, Negishi M (2004). "The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras.". Science 305 (5685): 862-5. doi:10.1126/science.1097545. PMID 15297673. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Harada A, Katoh H, Negishi M (2005). "Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells.". J. Biol. Chem. 280 (18): 18418-24. doi:10.1074/jbc.M411356200. PMID 15738000. 
  • Kim YS, Hori M, Yasuda K, Ozaki H (2006). "Differences in the gestational pattern of mRNA expression of the Rnd family in rat and human myometria.". Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 142 (4): 410-5. doi:10.1016/j.cbpa.2005.08.028. PMID 16311049. 
 This article on a gene on chromosome 12 is a stub. You can help Wikipedia by expanding it.
v • d • e
Rho family of GTPases
Most studied
Cdc42 subclass
Rac subclass
RhoBTB subclass
RhoBTB1 - RhoBTB2
RhoH subclass
Rho subclass
Rnd subclass
Rnd1 - Rnd2 - Rnd3
RhoD subclass