RNA uridylyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a RNA uridylyltransferase (EC 2.7.7.52) is an enzyme that catalyzes the chemical reaction

UTP + RNAn diphosphate + RNAn⁺1

Thus, the two substrates of this enzyme are UTP and RNAn, whereas its two products are diphosphate and RNAn+1.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is UTP:RNA uridylyltransferase. Other names in common use include terminal uridylyltransferase, and TUT.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 2E5G, 2IKF, 2NOM, 2Q0C, 2Q0D, 2Q0E, 2Q0F, and 2Q0G.

[edit] References

• IUBMB entry for 2.7.7.52
• BRENDA references for 2.7.7.52 (Recommended.)
• PubMed references for 2.7.7.52
• PubMed Central references for 2.7.7.52
• Google Scholar references for 2.7.7.52
• Zabel P, Dorssers L, Wernars K, Van Kammen A (1981). "Terminal uridylyl transferase of Vigna unguiculata: purification and characterization of an enzyme catalyzing the addition of a single UMP residue to the 3'-end of an RNA primer". Nucleic. Acids. Res. 9: 2433–53. doi:10.1093/nar/9.11.2433. PMID 6269049. 

[edit] External links

The CAS registry number for this enzyme class is 78519-53-6.

• IUBMB entry for 2.7.7.52

• KEGG entry for 2.7.7.52

• BRENDA entry for 2.7.7.52

• NiceZyme view of 2.7.7.52

• EC2PDB: PDB structures for 2.7.7.52

• PRIAM entry for 2.7.7.52

• PUMA2 entry for 2.7.7.52

• IntEnz: Integrated Enzyme entry for 2.7.7.52

• MetaCyc entry for 2.7.7.52

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050265: RNA uridylyltransferase

• AMIGO entry for GO code 0050265: RNA uridylyltransferase