RNA ligase (ATP)

From Wikipedia, the free encyclopedia

In enzymology, a RNA ligase (ATP) (EC 6.5.1.3) is an enzyme that catalyzes the chemical reaction

ATP + (ribonucleotide)n + (ribonucleotide)m AMP + diphosphate + (ribonucleotide)n⁺m

The 3 substrates of this enzyme are ATP, (ribonucleotide)n, and (ribonucleotide)m, whereas its 3 products are AMP, diphosphate, and (ribonucleotide)n+m.

This enzyme belongs to the family of ligases, specifically those forming phosphoric-ester bonds. The systematic name of this enzyme class is poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming). Other names in common use include polyribonucleotide synthase (ATP), RNA ligase, polyribonucleotide ligase, and ribonucleic ligase.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1VDX and 2C5U.

[edit] References

• IUBMB entry for 6.5.1.3
• BRENDA references for 6.5.1.3 (Recommended.)
• PubMed references for 6.5.1.3
• PubMed Central references for 6.5.1.3
• Google Scholar references for 6.5.1.3
• Silber R, Malathi VG, Hurwitz J (1972). "Purification and properties of bacteriophage T4-induced RNA ligase". Proc. Natl. Acad. Sci. U. S. A. 69: 3009–13. doi:10.1073/pnas.69.10.3009. PMID 4342972. 

[edit] External links

The CAS registry number for this enzyme class is 37353-39-2.

• IUBMB entry for 6.5.1.3

• KEGG entry for 6.5.1.3

• BRENDA entry for 6.5.1.3

• NiceZyme view of 6.5.1.3

• EC2PDB: PDB structures for 6.5.1.3

• PRIAM entry for 6.5.1.3

• PUMA2 entry for 6.5.1.3

• IntEnz: Integrated Enzyme entry for 6.5.1.3

• MetaCyc entry for 6.5.1.3

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0003972: RNA ligase (ATP)

• AMIGO entry for GO code 0003972: RNA ligase (ATP)