RNASEL

From Wikipedia, the free encyclopedia

Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)

PDB rendering based on 1wdy.

Available structures: 1wdy

Identifiers

Symbol(s)

RNASEL; RNS4; DKFZp781D08126; MGC104972; MGC133329; PRCA1

External IDs

OMIM: 180435 MGI: 1098272 HomoloGene: 8040

Gene ontology
Molecular Function:	• RNA binding • protein kinase activity • ATP binding • zinc ion binding • hydrolase activity • endoribonuclease activity, producing 5'-phosphomonoesters • metal ion binding
Cellular Component:	• cellular_component
Biological Process:	• mRNA processing • protein amino acid phosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021133 (mRNA)
NP_066956 (protein)

XM_985944 (mRNA)
XP_991038 (protein)

Location

Chr 1: 180.81 - 180.83 Mb

Chr 1: 155.52 - 155.52 Mb

Pubmed search

[1]

[2]

Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent), also known as RNASEL, is a human gene.

This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele.^[1]

[edit] References

^ Entrez Gene: RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent).

[edit] Further reading

Castelli J, Wood KA, Youle RJ (1999). "The 2-5A system in viral infection and apoptosis.". Biomed. Pharmacother. 52 (9): 386–90. PMID 9856285.
Leaman DW, Cramer H (1999). "Controlling gene expression with 2-5A antisense.". Methods 18 (3): 252–65. doi:10.1006/meth.1999.0782. PMID 10454983.
Silverman RH (2003). "Implications for RNase L in prostate cancer biology.". Biochemistry 42 (7): 1805–12. doi:10.1021/bi027147i. PMID 12590567.
Kieffer N, Schmitz M, Scheiden R, et al. (2006). "Involvement of the RNAse L gene in prostate cancer.". Bulletin de la Société des sciences médicales du Grand-Duché de Luxembourg (1): 21–8. PMID 16869093.
Bisbal C, Silverman RH (2007). "Diverse functions of RNase L and implications in pathology.". Biochimie 89 (6-7): 789–98. doi:10.1016/j.biochi.2007.02.006. PMID 17400356.
Carter BS, Beaty TH, Steinberg GD, et al. (1992). "Mendelian inheritance of familial prostate cancer.". Proc. Natl. Acad. Sci. U.S.A. 89 (8): 3367–71. PMID 1565627.
Squire J, Zhou A, Hassel BA, et al. (1994). "Localization of the interferon-induced, 2-5A-dependent RNase gene (RNS4) to human chromosome 1q25.". Genomics 19 (1): 174–5. doi:10.1006/geno.1994.1033. PMID 7514564.
Dong B, Xu L, Zhou A, et al. (1994). "Intrinsic molecular activities of the interferon-induced 2-5A-dependent RNase.". J. Biol. Chem. 269 (19): 14153–8. PMID 7514601.
Bisbal C, Martinand C, Silhol M, et al. (1995). "Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway.". J. Biol. Chem. 270 (22): 13308–17. PMID 7539425.
Zhou A, Hassel BA, Silverman RH (1993). "Expression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon action.". Cell 72 (5): 753–65. PMID 7680958.
Hassel BA, Zhou A, Sotomayor C, et al. (1993). "A dominant negative mutant of 2-5A-dependent RNase suppresses antiproliferative and antiviral effects of interferon.". EMBO J. 12 (8): 3297–304. PMID 7688298.
Smith JR, Freije D, Carpten JD, et al. (1996). "Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search.". Science 274 (5291): 1371–4. PMID 8910276.
Egesten A, Dyer KD, Batten D, et al. (1997). "Ribonucleases and host defense: identification, localization and gene expression in adherent monocytes in vitro.". Biochim. Biophys. Acta 1358 (3): 255–60. PMID 9366257.
Eeles RA, Durocher F, Edwards S, et al. (1998). "Linkage analysis of chromosome 1q markers in 136 prostate cancer families. The Cancer Research Campaign/British Prostate Group U.K. Familial Prostate Cancer Study Collaborators.". Am. J. Hum. Genet. 62 (3): 653–8. PMID 9497242.
Dong B, Silverman RH (1999). "Alternative function of a protein kinase homology domain in 2', 5'-oligoadenylate dependent RNase L.". Nucleic Acids Res. 27 (2): 439–45. PMID 9862963.
Carpten JD, Makalowska I, Robbins CM, et al. (2000). "A 6-Mb high-resolution physical and transcription map encompassing the hereditary prostate cancer 1 (HPC1) region.". Genomics 64 (1): 1–14. doi:10.1006/geno.1999.6051. PMID 10708513.
Zhou A, Nie H, Silverman RH (2001). "Analysis and origins of the human and mouse RNase L genes: mediators of interferon action.". Mamm. Genome 11 (11): 989–92. PMID 11063255.
Dong B, Niwa M, Walter P, Silverman RH (2001). "Basis for regulated RNA cleavage by functional analysis of RNase L and Ire1p.". RNA 7 (3): 361–73. PMID 11333017.