RNASE2

From Wikipedia, the free encyclopedia

Ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)

PDB rendering based on 1gqv.

Available structures: 1gqv, 1hi2, 1hi3, 1hi4, 1hi5, 1k2a, 2bex, 2bzz, 2c01, 2c02, 2c05

Identifiers

Symbol(s)

RNASE2; EDN; RNS2

External IDs

OMIM: 131410 MGI: 1858238 HomoloGene: 68284

Gene ontology
Molecular Function:	• nucleic acid binding • endonuclease activity • pancreatic ribonuclease activity • ribonuclease activity • hydrolase activity
Cellular Component:	• extracellular region • membrane • integral to membrane • MHC class II protein complex
Biological Process:	• antigen processing and presentation of peptide or polysaccharide antigen via MHC class II • RNA catabolic process • chemotaxis • immune response

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_002934 (mRNA)
NP_002925 (protein)

NM_001017422 (mRNA)
NP_001017422 (protein)

Location

Chr 14: 20.49 - 20.49 Mb

n/a

Pubmed search

[1]

[2]

Ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin), also known as RNASE2, is a human gene.^[1]

The protein encoded by this gene is found in eosinophil granulocytes.

1 References
2 Further reading
3 See also
4 External links

[edit] References

^ Entrez Gene: RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin).

[edit] Further reading

Rosenberg HF, Domachowske JB (2000). "Eosinophils, ribonucleases and host defense: solving the puzzle.". Immunol. Res. 20 (3): 261–74. PMID 10741866.
Abu-Ghazaleh RI, Dunnette SL, Loegering DA, et al. (1993). "Eosinophil granule proteins in peripheral blood granulocytes.". J. Leukoc. Biol. 52 (6): 611–8. PMID 1464733.
Mastrianni DM, Eddy RL, Rosenberg HF, et al. (1992). "Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14.". Genomics 13 (1): 240–2. PMID 1577491.
Sakakibara R, Hashida K, Kitahara T, Ishiguro M (1992). "Characterization of a unique nonsecretory ribonuclease from urine of pregnant women.". J. Biochem. 111 (3): 325–30. PMID 1587793.
Hamann KJ, Ten RM, Loegering DA, et al. (1990). "Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamily.". Genomics 7 (4): 535–46. PMID 2387583.
Hamann KJ, Barker RL, Loegering DA, et al. (1990). "Sequence of human eosinophil-derived neurotoxin cDNA: identity of deduced amino acid sequence with human nonsecretory ribonucleases.". Gene 83 (1): 161–7. PMID 2591744.
Rosenberg HF, Tenen DG, Ackerman SJ (1989). "Molecular cloning of the human eosinophil-derived neurotoxin: a member of the ribonuclease gene family.". Proc. Natl. Acad. Sci. U.S.A. 86 (12): 4460–4. PMID 2734298.
Barker RL, Loegering DA, Ten RM, et al. (1989). "Eosinophil cationic protein cDNA. Comparison with other toxic cationic proteins and ribonucleases.". J. Immunol. 143 (3): 952–5. PMID 2745977.
Beintema JJ, Hofsteenge J, Iwama M, et al. (1988). "Amino acid sequence of the nonsecretory ribonuclease of human urine.". Biochemistry 27 (12): 4530–8. PMID 3166997.
Sorrentino S, Tucker GK, Glitz DG (1988). "Purification and characterization of a ribonuclease from human liver.". J. Biol. Chem. 263 (31): 16125–31. PMID 3182786.
Gleich GJ, Loegering DA, Bell MP, et al. (1986). "Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease.". Proc. Natl. Acad. Sci. U.S.A. 83 (10): 3146–50. PMID 3458170.
Niwata Y, Ohgi K, Sanda A, et al. (1985). "Purification and properties of bovine kidney ribonucleases.". J. Biochem. 97 (3): 923–34. PMID 3926759.
de Beer T, Vliegenthart JF, Löffler A, Hofsteenge J (1995). "The hexopyranosyl residue that is C-glycosidically linked to the side chain of tryptophan-7 in human RNase Us is alpha-mannopyranose.". Biochemistry 34 (37): 11785–9. PMID 7547911.
Hofsteenge J, Müller DR, de Beer T, et al. (1994). "New type of linkage between a carbohydrate and a protein: C-glycosylation of a specific tryptophan residue in human RNase Us.". Biochemistry 33 (46): 13524–30. PMID 7947762.
Kardana A, Bagshawe KD, Coles B, et al. (1993). "Characterisation of UGP and its relationship with beta-core fragment.". Br. J. Cancer 67 (4): 686–92. PMID 8471426.
Mosimann SC, Newton DL, Youle RJ, James MN (1996). "X-ray crystallographic structure of recombinant eosinophil-derived neurotoxin at 1.83 A resolution.". J. Mol. Biol. 260 (4): 540–52. doi:10.1006/jmbi.1996.0420. PMID 8759319.
Krieg J, Hartmann S, Vicentini A, et al. (1998). "Recognition signal for C-mannosylation of Trp-7 in RNase 2 consists of sequence Trp-x-x-Trp.". Mol. Biol. Cell 9 (2): 301–9. PMID 9450956.
Sur S, Glitz DG, Kita H, et al. (1998). "Localization of eosinophil-derived neurotoxin and eosinophil cationic protein in neutrophilic leukocytes.". J. Leukoc. Biol. 63 (6): 715–22. PMID 9620664.
Zhang J, Rosenberg HF (2001). "Sequence variation at two eosinophil-associated ribonuclease loci in humans.". Genetics 156 (4): 1949–58. PMID 11102386.