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[edit] Summary

Overview of RNA interference. The dicer enzymes produce siRNA from double-stranded RNA and mature miRNA from precursor miRNA. miRNA or siRNA is bound to an argonaute enzyme and an effector complex is formed, either a RISC (RNA-induced silencing complex) or RITS (RNA-induced transcriptional silencing) complex. RITS affects the rate of transcription by histone and DNA methylation, whereas RISC degrades mRNA to prevent it from being translated.

This figure is adapted from one by Matzke MA, Matzke AJM (2004) Planting the Seeds of a New Paradigm. PLoS Biol 2(5): e133 doi:10.1371/journal.pbio.0020133.

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	Date/Time	Dimensions	User	Comment
current	23:06, 23 December 2007	800×684 (115 KB)	Narayanese (Talk \| contribs)
	22:35, 22 December 2007	800×684 (114 KB)	Narayanese (Talk \| contribs)
	22:22, 22 December 2007	800×684 (115 KB)	Narayanese (Talk \| contribs)
	10:17, 21 December 2007	800×684 (115 KB)	Narayanese (Talk \| contribs)	(Overview of RNA interference. This figure is adapted from one by Matzke MA, Matzke AJM (2004) Planting the Seeds of a New Paradigm. PLoS Biol 2(5): e133 [http://dx.doi.org/10.1371/journal.pbio.0020133].)