RIT2

From Wikipedia, the free encyclopedia

Ras-like without CAAX 2

Identifiers

RIT2; RIBA; RIN; ROC2

External IDs

OMIM: 609592 MGI: 108054 HomoloGene: 2198

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • calmodulin binding • GTP binding
Cellular Component:	• intracellular • plasma membrane
Biological Process:	• signal transduction • small GTPase mediated signal transduction • synaptic transmission

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002930 (mRNA)
NP_002921 (protein)

NM_009065 (mRNA)
NP_033091 (protein)

Location

Chr 18: 38.58 - 38.95 Mb

Chr 18: 31.12 - 31.46 Mb

Pubmed search

[1]

[2]

Ras-like without CAAX 2, also known as RIT2, is a human gene.^[1]

RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: RIT2 Ras-like without CAAX 2.

[edit] Further reading

Lee CH, Della NG, Chew CE, Zack DJ (1996). "Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins.". J. Neurosci. 16 (21): 6784–94. PMID 8824319.
Wes PD, Yu M, Montell C (1997). "RIC, a calmodulin-binding Ras-like GTPase.". EMBO J. 15 (21): 5839–48. PMID 8918462.
Shao H, Kadono-Okuda K, Finlin BS, Andres DA (1999). "Biochemical characterization of the Ras-related GTPases Rit and Rin.". Arch. Biochem. Biophys. 371 (2): 207–19. doi:10.1006/abbi.1999.1448. PMID 10545207.
Hoshino M, Nakamura S (2002). "The Ras-like small GTP-binding protein Rin is activated by growth factor stimulation.". Biochem. Biophys. Res. Commun. 295 (3): 651–6. PMID 12099688.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Calissano M, Latchman DS (2003). "Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor.". Oncogene 22 (35): 5408–14. doi:10.1038/sj.onc.1206635. PMID 12934100.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Hartwig C, Veske A, Krejcova S, et al. (2006). "Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin.". BMC neuroscience 6: 53. doi:10.1186/1471-2202-6-53. PMID 16122393.
Shi GX, Han J, Andres DA (2006). "Rin GTPase couples nerve growth factor signaling to p38 and b-Raf/ERK pathways to promote neuronal differentiation.". J. Biol. Chem. 280 (45): 37599–609. doi:10.1074/jbc.M507364200. PMID 16157584.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.