RIPK5

From Wikipedia, the free encyclopedia

Receptor interacting protein kinase 5

Identifiers

RIPK5; DustyPK; HDCMD38P; KIAA0472; RIP5

External IDs

MGI: 1925064 HomoloGene: 19711

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • ATP binding • transferase activity
Biological Process:	• protein amino acid phosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015375 (mRNA)
NP_056190 (protein)

NM_172516 (mRNA)
NP_766104 (protein)

Location

Chr 1: 203.38 - 203.45 Mb

Chr 1: 134.25 - 134.29 Mb

Pubmed search

[1]

[2]

Receptor interacting protein kinase 5, also known as RIPK5, is a human gene.^[1]

This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. Multiple alternatively spliced transcript variants have been found, but the biological validity of some variants has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: RIPK5 receptor interacting protein kinase 5.

[edit] Further reading

Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42-50. doi:10.1006/geno.1994.1457. PMID 7829101.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.". DNA Res. 4 (5): 345-9. PMID 9455484.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491-6. PMID 10737800.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Zha J, Zhou Q, Xu LG, et al. (2004). "RIP5 is a RIP-homologous inducer of cell death.". Biochem. Biophys. Res. Commun. 319 (2): 298-303. doi:10.1016/j.bbrc.2004.04.194. PMID 15178406.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Peng J, Dong W, Chen Y, et al. (2007). "Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain.". Biochim. Biophys. Acta 1759 (11-12): 562-72. doi:10.1016/j.bbaexp.2006.10.004. PMID 17123648.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.