RIPK4

From Wikipedia, the free encyclopedia

Receptor-interacting serine-threonine kinase 4

Identifiers

RIPK4; ANKK2; ANKRD3; DIK; MGC129992; MGC129993; PKK; RIP4

External IDs

OMIM: 605706 MGI: 1919638 HomoloGene: 10772

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • receptor activity • protein binding • ATP binding • transferase activity
Cellular Component:	• cellular_component
Biological Process:	• protein amino acid phosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_020639 (mRNA)
NP_065690 (protein)

NM_023663 (mRNA)
NP_076152 (protein)

Location

Chr 21: 42.03 - 42.06 Mb

Chr 16: 97.9 - 97.92 Mb

Pubmed search

[1]

[2]

Receptor-interacting serine-threonine kinase 4, also known as RIPK4, is a human gene.^[1]

The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation.^[1]

[edit] References

^ ^a ^b Entrez Gene: RIPK4 receptor-interacting serine-threonine kinase 4.

[edit] Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
Bhr C, Rohwer A, Stempka L, et al. (2000). "DIK, a novel protein kinase that interacts with protein kinase Cdelta. Cloning, characterization, and gene analysis.". J. Biol. Chem. 275 (46): 36350–7. doi:10.1074/jbc.M004771200. PMID 10948194.
Chen L, Haider K, Ponda M, et al. (2001). "Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase.". J. Biol. Chem. 276 (24): 21737–44. doi:10.1074/jbc.M008069200. PMID 11278382.
Meylan E, Martinon F, Thome M, et al. (2003). "RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis.". EMBO Rep. 3 (12): 1201–8. doi:10.1093/embo-reports/kvf236. PMID 12446564.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Moran ST, Haider K, Ow Y, et al. (2003). "Protein kinase C-associated kinase can activate NFkappaB in both a kinase-dependent and a kinase-independent manner.". J. Biol. Chem. 278 (24): 21526–33. doi:10.1074/jbc.M301575200. PMID 12676934.
Scanlan MJ, Gout I, Gordon CM, et al. (2003). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.". Cancer Immun. 1: 4. PMID 12747765.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Adams S, Pankow S, Werner S, Munz B (2007). "Regulation of NF-kappaB activity and keratinocyte differentiation by the RIP4 protein: implications for cutaneous wound repair.". J. Invest. Dermatol. 127 (3): 538–44. doi:10.1038/sj.jid.5700588. PMID 17039240.