RIPK2

From Wikipedia, the free encyclopedia

Receptor-interacting serine-threonine kinase 2

Identifiers

RIPK2; CCK; CARD3; CARDIAK; GIG30; RICK; RIP2

External IDs

OMIM: 603455 MGI: 1891456 HomoloGene: 37856

Gene ontology
Molecular Function:	• nucleotide binding • protein kinase activity • protein serine/threonine kinase activity • signal transducer activity • receptor activity • protein binding • ATP binding • transferase activity • LIM domain binding • CARD domain binding
Cellular Component:	• intracellular
Biological Process:	• protein amino acid phosphorylation • inflammatory response • signal transduction • positive regulation of apoptosis • positive regulation of I-kappaB kinase/NF-kappaB cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003821 (mRNA)
NP_003812 (protein)

NM_138952 (mRNA)
NP_620402 (protein)

Location

Chr 8: 90.84 - 90.87 Mb

Chr 4: 16.05 - 16.09 Mb

Pubmed search

[1]

[2]

Receptor-interacting serine-threonine kinase 2, also known as RIPK2, is a human gene.^[1]

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.^[1]

[edit] References

^ ^a ^b Entrez Gene: RIPK2 receptor-interacting serine-threonine kinase 2.

[edit] Further reading

Medzhitov R, Janeway C (2000). "Innate immune recognition: mechanisms and pathways.". Immunol. Rev. 173: 89–97. PMID 10719670.
Dufner A, Mak TW (2006). "CARD tricks: controlling the interactions of CARD6 with RICK and microtubules.". Cell Cycle 5 (8): 797–800. PMID 16582588.
Inohara N, del Peso L, Koseki T, et al. (1998). "RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis.". J. Biol. Chem. 273 (20): 12296–300. PMID 9575181.
McCarthy JV, Ni J, Dixit VM (1998). "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.". J. Biol. Chem. 273 (27): 16968–75. PMID 9642260.
Thome M, Hofmann K, Burns K, et al. (1998). "Identification of CARDIAK, a RIP-like kinase that associates with caspase-1.". Curr. Biol. 8 (15): 885–8. PMID 9705938.
Bertin J, Nir WJ, Fischer CM, et al. (1999). "Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB.". J. Biol. Chem. 274 (19): 12955–8. PMID 10224040.
Inohara N, Koseki T, del Peso L, et al. (1999). "Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB.". J. Biol. Chem. 274 (21): 14560–7. PMID 10329646.
Navas TA, Baldwin DT, Stewart TA (1999). "RIP2 is a Raf1-activated mitogen-activated protein kinase kinase.". J. Biol. Chem. 274 (47): 33684–90. PMID 10559258.
Inohara N, Koseki T, Lin J, et al. (2000). "An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways.". J. Biol. Chem. 275 (36): 27823–31. doi:10.1074/jbc.M003415200. PMID 10880512.
Ogura Y, Inohara N, Benito A, et al. (2001). "Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB.". J. Biol. Chem. 276 (7): 4812–8. doi:10.1074/jbc.M008072200. PMID 11087742.
Lee SH, Stehlik C, Reed JC (2001). "Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing.". J. Biol. Chem. 276 (37): 34495–500. doi:10.1074/jbc.M101415200. PMID 11432859.
Khursigara G, Bertin J, Yano H, et al. (2001). "A prosurvival function for the p75 receptor death domain mediated via the caspase recruitment domain receptor-interacting protein 2.". J. Neurosci. 21 (16): 5854–63. PMID 11487608.
Druilhe A, Srinivasula SM, Razmara M, et al. (2001). "Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins.". Cell Death Differ. 8 (6): 649–57. doi:10.1038/sj/cdd/4400881. PMID 11536016.
Chin AI, Dempsey PW, Bruhn K, et al. (2002). "Involvement of receptor-interacting protein 2 in innate and adaptive immune responses.". Nature 416 (6877): 190–4. doi:10.1038/416190a. PMID 11894097.
Kobayashi K, Inohara N, Hernandez LD, et al. (2002). "RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems.". Nature 416 (6877): 194–9. doi:10.1038/416194a. PMID 11894098.
Munz B, Hildt E, Springer ML, Blau HM (2002). "RIP2, a checkpoint in myogenic differentiation.". Mol. Cell. Biol. 22 (16): 5879–86. PMID 12138198.
Yoo NJ, Park WS, Kim SY, et al. (2003). "Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1.". Biochem. Biophys. Res. Commun. 299 (4): 652–8. PMID 12459189.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Chen YR, Clark AC (2003). "Equilibrium and kinetic folding of an alpha-helical Greek key protein domain: caspase recruitment domain (CARD) of RICK.". Biochemistry 42 (20): 6310–20. doi:10.1021/bi0340752. PMID 12755636.