Ribulose-phosphate 3-epimerase

From Wikipedia, the free encyclopedia

In enzymology, a ribulose-phosphate 3-epimerase (EC 5.1.3.1) is an enzyme that catalyzes the chemical reaction

D-ribulose 5-phosphate D-xylulose 5-phosphate

Hence, this enzyme has one substrate, D-ribulose 5-phosphate, and one product, D-xylulose 5-phosphate.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is D-ribulose-5-phosphate 3-epimerase. Other names in common use include phosphoribulose epimerase, erythrose-4-phosphate isomerase, phosphoketopentose 3-epimerase, xylulose phosphate 3-epimerase, phosphoketopentose epimerase, ribulose 5-phosphate 3-epimerase, D-ribulose phosphate-3-epimerase, D-ribulose 5-phosphate epimerase, D-ribulose-5-P 3-epimerase, D-xylulose-5-phosphate 3-epimerase, and pentose-5-phosphate 3-epimerase. This enzyme participates in 3 metabolic pathways: pentose phosphate pathway, pentose and glucuronate interconversions, and carbon fixation.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1H1Y, 1H1Z, 1RPX, and 1TQJ.

[edit] References

• IUBMB entry for 5.1.3.1
• BRENDA references for 5.1.3.1 (Recommended.)
• PubMed references for 5.1.3.1
• PubMed Central references for 5.1.3.1
• Google Scholar references for 5.1.3.1
• Ashwell G and Hickman J (1957). "Enzymatic formation of xylulose 5-phosphate from ribose 5-phosphate in spleen". J. Biol. Chem. 226: 65–76. 
• DICKENS F, WILLIAMSON DH (1956). "Pentose phosphate isomerase and epimerase from animal tissues". Biochem. J. 64: 567–78. PMID 13373810. 
• Hurwitz J and Horecker BL (1956). "The purification of phosphoketopentoepimerase from Lactobacillus pentosus and the preparation of xylulose 5-phosphate". J. Biol. Chem. 223: 993–1008. 
• Stumpf PK and Horecker BL (1956). "The roole of xylulose 5-phosphate in xylose metabolism of Lactobacillus pentosus". J. Biol. Chem. 218: 753–768. 
• Terada T, Mukae H, Ohashi K, Hosomi S, Mizoguchi T, Uehara K (1985). "Characterization of an enzyme which catalyzes isomerization and epimerization of D-erythrose 4-phosphate". Eur. J. Biochem. 148: 345–51. doi:10.1111/j.1432-1033.1985.tb08845.x. PMID 3987693. 

[edit] External links

The CAS registry number for this enzyme class is 9024-20-8.

• IUBMB entry for 5.1.3.1

• KEGG entry for 5.1.3.1

• BRENDA entry for 5.1.3.1

• NiceZyme view of 5.1.3.1

• EC2PDB: PDB structures for 5.1.3.1

• PRIAM entry for 5.1.3.1

• PUMA2 entry for 5.1.3.1

• IntEnz: Integrated Enzyme entry for 5.1.3.1

• MetaCyc entry for 5.1.3.1

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004750: ribulose-phosphate 3-epimerase

• AMIGO entry for GO code 0004750: ribulose-phosphate 3-epimerase