Ribose-5-phosphate isomerase

From Wikipedia, the free encyclopedia

In enzymology, a ribose-5-phosphate isomerase (EC 5.3.1.6) is an enzyme that catalyzes the chemical reaction

D-ribose 5-phosphate $\rightleftharpoons$ D-ribulose 5-phosphate

Hence, this enzyme has one substrate, D-ribose 5-phosphate, and one product, D-ribulose 5-phosphate.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The systematic name of this enzyme class is D-ribose-5-phosphate aldose-ketose-isomerase. Other names in common use include phosphopentosisomerase, phosphoriboisomerase, ribose phosphate isomerase, 5-phosphoribose isomerase, D-ribose 5-phosphate isomerase, and D-ribose-5-phosphate ketol-isomerase. This enzyme participates in pentose phosphate pathway and carbon fixation.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 15 structures have been solved for this class of enzymes, with PDB accession codes 1LK5, 1LK7, 1LKZ, 1M0S, 1NN4, 1O1X, 1O8B, 1UJ4, 1UJ5, 1UJ6, 1USL, 1XTZ, 2BES, 2BET, and 2F8M.

[edit] References

IUBMB entry for 5.3.1.6
BRENDA references for 5.3.1.6 (Recommended.)
PubMed references for 5.3.1.6
PubMed Central references for 5.3.1.6
Google Scholar references for 5.3.1.6
DICKENS F, WILLIAMSON DH (1956). "Pentose phosphate isomerase and epimerase from animal tissues". Biochem. J. 64: 567–78. PMID 13373810.
HORECKER BL, SMYRNIOTIS PZ, SEEGMILLER JE (1951). "The enzymatic conversion of 6-phosphogluconate to ribulose-5-phosphate and ribose-5-phosphate". J. Biol. Chem. 193: 383–96. PMID 14907726.
HURWITZ J, WEISSBACH A, HORECKER BL, SMYRNIOTIS PZ (1956). "Spinach phosphoribulokinase". J. Biol. Chem. 218: 769–83. PMID 13295229.