Ribose-5-phosphate-ammonia ligase

From Wikipedia, the free encyclopedia

In enzymology, a ribose-5-phosphate-ammonia ligase (EC 6.3.4.7) is an enzyme that catalyzes the chemical reaction

ATP + ribose 5-phosphate + NH₃ ADP + phosphate + 5-phosphoribosylamine

The 3 substrates of this enzyme are ATP, ribose 5-phosphate, and NH₃, whereas its 3 products are ADP, phosphate, and 5-phosphoribosylamine.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is ribose-5-phosphate:ammonia ligase (ADP-forming). Other names in common use include 5-phosphoribosylamine synthetase, ribose 5-phosphate aminotransferase, and ammonia-ribose 5-phosphate aminotransferase. This enzyme participates in purine metabolism.

[edit] References

• IUBMB entry for 6.3.4.7
• BRENDA references for 6.3.4.7 (Recommended.)
• PubMed references for 6.3.4.7
• PubMed Central references for 6.3.4.7
• Google Scholar references for 6.3.4.7
• Reem GH (1968). "Enzymatic synthesis of 5'-phosphoribosylamine from ribose 5-phosphate and ammonia, an alternate first step in purine biosynthesis". J. Biol. Chem. 243: 5695–701. PMID 5699059. 

[edit] External links

The CAS registry number for this enzyme class is 9082-52-4.

• IUBMB entry for 6.3.4.7

• KEGG entry for 6.3.4.7

• BRENDA entry for 6.3.4.7

• NiceZyme view of 6.3.4.7

• EC2PDB: PDB structures for 6.3.4.7

• PRIAM entry for 6.3.4.7

• PUMA2 entry for 6.3.4.7

• IntEnz: Integrated Enzyme entry for 6.3.4.7

• MetaCyc entry for 6.3.4.7

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050260: ribose-5-phosphate-ammonia ligase

• AMIGO entry for GO code 0050260: ribose-5-phosphate-ammonia ligase