RhoH

From Wikipedia, the free encyclopedia


Ras homolog gene family, member H
Identifiers
Symbol(s) RHOH; ARHH; TTF
External IDs OMIM: 602037 MGI: 1921984 HomoloGene: 3180
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 399 74734
Ensembl ENSG00000168421 ENSMUSG00000029204
Uniprot Q15669 Q3TEI3
Refseq NM_004310 (mRNA)
NP_004301 (protein)		 XM_132051 (mRNA)
XP_132051 (protein)
Location Chr 4: 39.87 - 39.92 Mb Chr 5: 66.14 - 66.17 Mb
Pubmed search [1] [2]

RhoH (Ras homolog gene family, member H) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.[1] It is encoded by the gene RHOH[2].

[edit] Gene

Expression of a chimeric transcript of LAZ3 and this gene has been reported as a result of the translocation t(3;4) in non-Hodgkin's lymphomas. Unlike most other small G proteins which are expressed ubiquitously, this gene is transcribed only in hemopoietic cells.[2] }}

[edit] References

  1. ^ Ridley A. (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. ISSN 0962-8924. 
  2. ^ a b Entrez Gene: RHOH ras homolog gene family, member H.

[edit] Further reading

  • Dallery E, Galiègue-Zouitina S, Collyn-d'Hooghe M, et al. (1995). "TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation.". Oncogene 10 (11): 2171–8. PMID 7784061. 
  • Dallery-Prudhomme E, Roumier C, Denis C, et al. (1997). "Genomic structure and assignment of the RhoH/TTF small GTPase gene (ARHH) to 4p13 by in situ hybridization.". Genomics 43 (1): 89–94. doi:10.1006/geno.1997.4788. PMID 9226377. 
  • Yousefi S, Cooper PR, Mueck B, et al. (2000). "cDNA representational difference analysis of human neutrophils stimulated by GM-CSF.". Biochem. Biophys. Res. Commun. 277 (2): 401–9. doi:10.1006/bbrc.2000.3678. PMID 11032736. 
  • Fauré J, Dagher MC (2001). "Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI).". Biochimie 83 (5): 409–14. PMID 11368848. 
  • Li X, Bu X, Lu B, et al. (2002). "The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function.". Mol. Cell. Biol. 22 (4): 1158–71. PMID 11809807. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Lahousse S, Smorowski AL, Denis C, et al. (2005). "Structural features of hematopoiesis-specific RhoH/ARHH gene: high diversity of 5'-UTR in different hematopoietic lineages suggests a complex post-transcriptional regulation.". Gene 343 (1): 55–68. doi:10.1016/j.gene.2004.08.022. PMID 15563831. 
  • Lopez-Ilasaca MA, Bernabe-Ortiz JC, Na SY, et al. (2005). "Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells.". FEBS Lett. 579 (3): 648–54. doi:10.1016/j.febslet.2004.12.039. PMID 15670823. 
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Reiniger L, Bödör C, Bognár A, et al. (2006). "Richter's and prolymphocytic transformation of chronic lymphocytic leukemia are associated with high mRNA expression of activation-induced cytidine deaminase and aberrant somatic hypermutation.". Leukemia 20 (6): 1089–95. doi:10.1038/sj.leu.2404183. PMID 16541139. 
  • Hiraga J, Katsumi A, Iwasaki T, et al. (2007). "Prognostic analysis of aberrant somatic hypermutation of RhoH gene in diffuse large B cell lymphoma.". Leukemia 21 (8): 1846–7. doi:10.1038/sj.leu.2404717. PMID 17443219. 
  • Traverse-Glehen A, Verney A, Baseggio L, et al. (2007). "Analysis of BCL-6, CD95, PIM1, RHO/TTF and PAX5 mutations in splenic and nodal marginal zone B-cell lymphomas suggests a particular B-cell origin.". Leukemia 21 (8): 1821–4. doi:10.1038/sj.leu.2404706. PMID 17476282. 
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v • d • e
Rho family of GTPases
Most studied
Cdc42 subclass
Rac subclass
RhoBTB subclass
RhoBTB1 - RhoBTB2
RhoH subclass
RhoH
Rho subclass
Rnd subclass
RhoD subclass