RhoGEF domain

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RhoGEF domain
Identifiers
Symbol	RhoGEF
Pfam	PF00621
InterPro	IPR000219
SMART	RhoGEF
SCOP	1dbh
OPM protein	1xd4
Available PDB structures: 1foeE:1044-1233 1f5xA:198-372 1ki1D:1241-1422 1ntyA:1237-1407 1kzgC:636-811 1lb1C:636-811 1kz7C:636-811 1rj2D:511-686 1xcgE:738-922 1txdA:791-976 1x86E:791-976 1by1A:275-450 1dbhA:204-389 1xdvB:204-389 1xd4A:204-389

RhoGEF domain is a structural domain of guanine nucleotide exchange factors for Rho/Rac/Cdc42-like GTPases. It is also called "Dbl-homologous" (DH) domain.

[edit] Subfamilies

• Guanine-nucleotide dissociation stimulator, CDC24 IPR001331

[edit] Human proteins containing this domain

ABR; AKAP13; ARHGEF1; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF15; ARHGEF16; ARHGEF17; ARHGEF18; ARHGEF19; ARHGEF2; ARHGEF3; ARHGEF4; ARHGEF5; ARHGEF6; ARHGEF7; ARHGEF9; ASEF2; BCR; C9orf100; DEPDC2; DNMBP; ECT2; FARP1; FARP2; FGD1; FGD2; FGD3; FGD4; FGD5; FGD6; GEFT; ITSN1; ITSN2; KALRN; LFDH; MCF2; MCF2L; MCF2L2; NET1; NGEF; OBSCN; PLEKHG1; PLEKHG2; PLEKHG3; PLEKHG4; PLEKHG5; PLEKHG6; PREX1; RASGRF1; SGEF; SOS1; SOS2; SPATA13; TIAM1; TIAM2; TRIO; VAV1; VAV2; VAV3;

[edit] References

• [1]. The Dbl family of oncogenes. Cerione RA, Zheng Y; Curr Opin Cell Biol 1996;8:216-222. PubMed
• [2]. Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product. Hart MJ, Eva A, Evans T, Aaronson SA, Cerione RA; Nature 1991;354:311-314. PubMed
• [3]. The human active breakpoint cluster region-related gene encodes a brain protein with homology to guanine nucleotide exchange proteins and GTPase-activating proteins. Tan EC, Leung T, Manser E, Lim L; J Biol Chem 1993;268:27291-27298. PubMed
• [4]. Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein. Soisson SM, Nimnual AS, Uy M, Bar-Sagi D, Kuriyan J; Cell 1998;95:259-268. PubMed