RhoGAP domain

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RhoGAP domain
Identifiers
Symbol	RhoGAP
Pfam	PF00620
InterPro	IPR000198
SMART	RhoGAP
PROSITE	PDOC50238
SCOP	1rgb
OPM protein	1xa6
Available PDB structures: 1xa6A:291-444 1f7cA:199-355 1am4B:260-408 1grnB:260-408 1ow3A:260-408 1rgp :260-402 1tx4A:260-408 2ngrB:260-408 1pbwB:129-281

RhoGAP domain is an evolutionary conserved protein domain of GTPase activating proteins towards Rho/Rac/Cdc42-like small GTPases.

[edit] Human proteins containing this domain

ABR; ARHGAP1; ARHGAP10; ARHGAP11A; ARHGAP11B; ARHGAP12; ARHGAP15; ARHGAP17; ARHGAP18; ARHGAP19; ARHGAP20; ARHGAP21; ARHGAP22; ARHGAP23; ARHGAP24; ARHGAP25; ARHGAP26; ARHGAP27; ARHGAP28; ARHGAP29; ARHGAP30; ARHGAP4; ARHGAP5; ARHGAP6; ARHGAP8; ARHGAP9; BCR; BPGAP1; C1; C5orf5; CDGAP; CENTD1; CENTD2; CENTD3; CHN1; CHN2; DEPDC1; DEPDC1A; DEPDC1B; DLC1; FAM13A1; FKSG42; GMIP; GRLF1; HMHA1; INPP5B; KIAA1688; LOC553158; MYO9A; MYO9B; OCRL; OPHN1; PIK3R1; PIK3R2; PRR5; RACGAP1; RACGAP1P; RALBP1; RICH2; RICS; SH3BP1; SLIT1; SNX26; SRGAP1; SRGAP2; SRGAP3; STARD13; STARD8; SYDE1; SYDE2;

[edit] References

• [1]. Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit. Musacchio A, Cantley LC, Harrison SC; Proc Natl Acad Sci U S A 1996;93:14373-14378. PubMed
• [2]. The structure of the GTPase-activating domain from p50rhoGAP. Barrett T, Xiao B, Dodson EJ, Dodson G, Ludbrook SB, Nurmahomed K, Gamblin SJ, Musacchio A, Smerdon SJ, Eccleston JF; Nature 1997;385:458-461. PubMed
• [3]. Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP. Rittinger K, Walker PA, Eccleston JF, Nurmahomed K, Owen D, Laue E, Gamblin SJ, Smerdon SJ; Nature 1997;388:693-697. PubMed
• [4]. Proteins regulating Ras and its relatives. Boguski MS, McCormick F; Nature 1993;366:643-654. PubMed