RhoD

From Wikipedia, the free encyclopedia


Ras homolog gene family, member D
PDB rendering based on 2j1l.
Available structures: 2j1l
Identifiers
Symbol(s) RHOD; ARHD; RHOHP1; RHOM; Rho
External IDs OMIM: 605781 MGI: 108446 HomoloGene: 22409
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 29984 11854
Ensembl ENSG00000173156 ENSMUSG00000041845
Uniprot O00212 Q545H8
Refseq NM_014578 (mRNA)
NP_055393 (protein)		 NM_007485 (mRNA)
NP_031511 (protein)
Location Chr 11: 66.58 - 66.6 Mb Chr 19: 4.43 - 4.44 Mb
Pubmed search [1] [2]

RhoD (Ras homolog gene family, member D) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.[1] It is encoded by the gene RHOD. [2]

It binds GTP and is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. [2]

[edit] References

  1. ^ Ridley A. (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. ISSN 0962-8924. 
  2. ^ a b Entrez Gene: RHOD ras homolog gene family, member D.

[edit] Further reading

  • Ridley AJ (2001). "Rho proteins: linking signaling with membrane trafficking.". Traffic 2 (5): 303–10. PMID 11350626. 
  • Shimizu F, Watanabe TK, Okuno S, et al. (1997). "Isolation of a novel human cDNA (rhoHP1) homologous to rho genes.". Biochim. Biophys. Acta 1351 (1-2): 13–6. PMID 9116026. 
  • Kim HS, Choi JY, Jung AR, et al. (2000). "Assignment of the human RhoHP1 gene (ARHD) to chromosome 11q14.3 by radiation hybrid mapping.". Cytogenet. Cell Genet. 89 (1-2): 53. PMID 10894936. 
  • Murphy C, Saffrich R, Olivo-Marin JC, et al. (2001). "Dual function of rhoD in vesicular movement and cell motility.". Eur. J. Cell Biol. 80 (6): 391–8. PMID 11484930. 
  • Zanata SM, Hovatta I, Rohm B, Püschel AW (2002). "Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse.". J. Neurosci. 22 (2): 471–7. PMID 11784792. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gasman S, Kalaidzidis Y, Zerial M (2003). "RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase.". Nat. Cell Biol. 5 (3): 195–204. doi:10.1038/ncb935. PMID 12577064. 
  • Jaffe AB, Aspenström P, Hall A (2004). "Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways.". Mol. Cell. Biol. 24 (4): 1736–46. PMID 14749388. 
  • Flaxenburg JA, Melter M, Lapchak PH, et al. (2004). "The CD40-induced signaling pathway in endothelial cells resulting in the overexpression of vascular endothelial growth factor involves Ras and phosphatidylinositol 3-kinase.". J. Immunol. 172 (12): 7503–9. PMID 15187129. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153. 
  • Birukova AA, Chatchavalvanich S, Rios A, et al. (2006). "Differential regulation of pulmonary endothelial monolayer integrity by varying degrees of cyclic stretch.". Am. J. Pathol. 168 (5): 1749–61. PMID 16651639. 
  • Ito Y, Kanamaru A, Tada A (2007). "A novel agent, methylophiopogonanone B, promotes Rho activation and tubulin depolymerization.". Mol. Cell. Biochem. 297 (1-2): 121–9. doi:10.1007/s11010-006-9336-y. PMID 17029007. 
  • Tan W, Martin D, Gutkind JS (2007). "The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4.". J. Biol. Chem. 281 (51): 39542–9. doi:10.1074/jbc.M609062200. PMID 17056591. 
  • Lakshman N, Kim A, Bayless KJ, et al. (2007). "Rho plays a central role in regulating local cell-matrix mechanical interactions in 3D culture.". Cell Motil. Cytoskeleton 64 (6): 434–45. doi:10.1002/cm.20194. PMID 17342762. 
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v • d • e
Rho family of GTPases
Most studied
Cdc42 subclass
Rac subclass
RhoBTB subclass
RhoBTB1 - RhoBTB2
RhoH subclass
Rho subclass
Rnd subclass
RhoD subclass
RhoD - Rif