RHOJ

From Wikipedia, the free encyclopedia

Ras homolog gene family, member J

Identifiers

RHOJ; ARHJ; FLJ14445; MGC34777; RASL7B; TC10B; TCL

External IDs

OMIM: 607653 MGI: 1931551 HomoloGene: 56894

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • protein binding • GTP binding
Cellular Component:	• cellular_component • intracellular • membrane
Biological Process:	• small GTPase mediated signal transduction • Rho protein signal transduction • regulation of cell shape • actin cytoskeleton organization and biogenesis

Orthologs

Human

Mouse

Refseq

NM_020663 (mRNA)
NP_065714 (protein)

NM_023275 (mRNA)
NP_075764 (protein)

Location

Chr 14: 62.74 - 62.83 Mb

Chr 12: 76.23 - 76.32 Mb

Pubmed search

[1]

[2]

Ras homolog gene family, member J, also known as RHOJ, is a human gene.^[1]

ARHJ belongs to the Rho family of small GTP-binding proteins. Rho proteins regulate the dynamic assembly of cytoskeletal components for several physiologic processes, such as cell proliferation and motility and the establishment of cell polarity. They are also involved in pathophysiologic process, such as cell transformation and metastasis.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: RHOJ ras homolog gene family, member J.

[edit] Further reading

Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621-5. doi:10.1126/science.1105776. PMID 15761153.
Nishikimi A, Meller N, Uekawa N, et al. (2005). "Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes.". FEBS Lett. 579 (5): 1039-46. doi:10.1016/j.febslet.2005.01.006. PMID 15710388.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ruusala A, Aspenström P (2004). "Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology.". FEBS Lett. 572 (1-3): 159-66. doi:10.1016/j.febslet.2004.06.095. PMID 15304341.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
de Toledo M, Senic-Matuglia F, Salamero J, et al. (2004). "The GTP/GDP cycling of rho GTPase TCL is an essential regulator of the early endocytic pathway.". Mol. Biol. Cell 14 (12): 4846-56. doi:10.1091/mbc.E03-04-0254. PMID 12960428.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Vignal E, De Toledo M, Comunale F, et al. (2000). "Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42.". J. Biol. Chem. 275 (46): 36457-64. doi:10.1074/jbc.M003487200. PMID 10967094.