RHOB

From Wikipedia, the free encyclopedia


Ras homolog gene family, member B
PDB rendering based on 2fv8.
Available structures: 2fv8
Identifiers
Symbol(s) RHOB; ARH6; ARHB; MST081; MSTP081; RHOH6
External IDs OMIM: 165370 MGI: 107949 HomoloGene: 68377
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 388 11852
Ensembl ENSG00000143878 ENSMUSG00000054364
Uniprot P62745 Q3TIC2
Refseq NM_004040 (mRNA)
NP_004031 (protein)		 NM_007483 (mRNA)
NP_031509 (protein)
Location Chr 2: 20.51 - 20.51 Mb Chr 12: 8.53 - 8.53 Mb
Pubmed search [1] [2]

Ras homolog gene family, member B, also known as RHOB, is a human gene.[1]

RHOB is a member of the Rho GTP-binding protein family.

[edit] References

  1. ^ Entrez Gene: RHOB ras homolog gene family, member B.

[edit] Further reading

  • Casey PJ, Seabra MC (1996). "Protein prenyltransferases.". J. Biol. Chem. 271 (10): 5289–92. PMID 8621375. 
  • Adamson P, Marshall CJ, Hall A, Tilbrook PA (1992). "Post-translational modifications of p21rho proteins.". J. Biol. Chem. 267 (28): 20033–8. PMID 1400319. 
  • Cannizzaro LA, Madaule P, Hecht F, et al. (1990). "Chromosome localization of human ARH genes, a ras-related gene family.". Genomics 6 (2): 197–203. PMID 2407642. 
  • Chardin P, Madaule P, Tavitian A (1988). "Coding sequence of human rho cDNAs clone 6 and clone 9.". Nucleic Acids Res. 16 (6): 2717. PMID 3283705. 
  • Madaule P, Axel R (1985). "A novel ras-related gene family.". Cell 41 (1): 31–40. PMID 3888408. 
  • Robertson D, Paterson HF, Adamson P, et al. (1995). "Ultrastructural localization of ras-related proteins using epitope-tagged plasmids.". J. Histochem. Cytochem. 43 (5): 471–80. PMID 7537292. 
  • Armstrong SA, Hannah VC, Goldstein JL, Brown MS (1995). "CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB.". J. Biol. Chem. 270 (14): 7864–8. PMID 7713879. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. 
  • Zalcman G, Closson V, Camonis J, et al. (1997). "RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG.". J. Biol. Chem. 271 (48): 30366–74. PMID 8939998. 
  • Mellor H, Flynn P, Nobes CD, et al. (1998). "PRK1 is targeted to endosomes by the small GTPase, RhoB.". J. Biol. Chem. 273 (9): 4811–4. PMID 9478917. 
  • Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169–76. PMID 9734811. 
  • Liu JP, Jessell TM (1999). "A role for rhoB in the delamination of neural crest cells from the dorsal neural tube.". Development 125 (24): 5055–67. PMID 9811589. 
  • Gampel A, Parker PJ, Mellor H (2000). "Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB.". Curr. Biol. 9 (17): 955–8. PMID 10508588. 
  • Matarrese P, Conti L, Varano B, et al. (2000). "The HIV-1 vpr protein induces anoikis-resistance by modulating cell adhesion process and microfilament system assembly.". Cell Death Differ. 7 (1): 25–36. doi:10.1038/sj.cdd.4400616. PMID 10713718. 
  • Liu A, Du W, Liu JP, et al. (2000). "RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors.". Mol. Cell. Biol. 20 (16): 6105–13. PMID 10913192. 
  • Michaelson D, Silletti J, Murphy G, et al. (2001). "Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding.". J. Cell Biol. 152 (1): 111–26. PMID 11149925. 
  • Liu Ax , Cerniglia GJ, Bernhard EJ, Prendergast GC (2001). "RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage.". Proc. Natl. Acad. Sci. U.S.A. 98 (11): 6192–7. doi:10.1073/pnas.111137198. PMID 11353846. 
  • Diviani D, Soderling J, Scott JD (2001). "AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation.". J. Biol. Chem. 276 (47): 44247–57. doi:10.1074/jbc.M106629200. PMID 11546812. 
  • Adnane J, Seijo E, Chen Z, et al. (2002). "RhoB, not RhoA, represses the transcription of the transforming growth factor beta type II receptor by a mechanism involving activator protein 1.". J. Biol. Chem. 277 (10): 8500–7. doi:10.1074/jbc.M104367200. PMID 11741970. 

[edit] See also

 This article on a gene on chromosome 2 is a stub. You can help Wikipedia by expanding it.
v • d • e
Acid anhydride hydrolases: GTPases/G proteins (EC 3.6.5)
3.6.5.1: Heterotrimeric G protein
3.6.5.2: Small GTPase > Ras superfamily
Ras - Rab (Rab27) - Arf (Arf6) - Ran - Rheb - Rho family (RhoA, RhoB, CDC42, Rac1) - Rap
3.6.5.3: Elongation factor
3.6.5.5-6: Other
Dynamin (is a GTPase, is not a G protein) - Tubulin
v • d • e
Rho family of GTPases
Most studied
Cdc42 subclass
Rac subclass
RhoBTB subclass
RhoBTB1 - RhoBTB2
RhoH subclass
Rho subclass
Rnd subclass
RhoD subclass